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Davignon J, Simmonds WJ, Ahrens EH. Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function. J Clin Invest. 1968;47(1):127-38doi: 10.1172/JCI105703.
Davignon, J., Simmonds, W. J., & Ahrens, E. H. (1968). Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function. The Journal of clinical investigation, 47(1), 127-38. https://doi.org/10.1172/JCI105703
Davignon, J, et al. "Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function." The Journal of clinical investigation vol. 47,1 (1968): 127-38. doi: https://doi.org/10.1172/JCI105703
Davignon J, Simmonds WJ, Ahrens EH. Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function. J Clin Invest. 1968 Jan;47(1):127-38. doi: 10.1172/JCI105703. PMID: 16695935; PMCID: PMC297154.
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J Clin Invest. 1968 Jan;47(1):127-38. doi: 10.1172/JCI105703.

Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function.

The Journal of clinical investigation

J Davignon, W J Simmonds, E H Ahrens

Affiliations

  1. The Rockefeller University, New York.

PMID: 16695935 PMCID: PMC297154 DOI: 10.1172/JCI105703

Abstract

In 35 patients maintained solely on liquid formula diets, chromic oxide has been evaluated as an internal standard for balance studies that require stool collections. In 28 patients the excretion of chromic oxide was ideal: steady states were attained in which mean daily output was 90% (or more) of mean daily intake. In these patients corrections for fecal flow could validly be applied.In patients who excreted the marker ideally, the availability of chromic oxide balance data made possible the calculation of pool sizes and turnover rates of unexcreted intestinal content. These indexes bore little relationship to the usual clinical descriptions of bowel habits. In some patient who had daily bowel movements, pool sizes were very large and daily turnover was small, i.e., a large proportion of the colonic contents was not excreted for surprisingly long periods. It is critically important for investigators to recognize this possibility when carrying out balance studies for fecal constituents that may be altered by bacterial action within the gut lumen: for instance, in 6 patients a significant inverse correlation was found between daily fecal turnover and degradative losses of large amounts of dietary beta-sitosterol.7 of 35 patients failed to attain the ideal steady state of chromic oxide excretion. These patients would not have been singled out if an internal standard had not been used. In such patients balance studies that require analysis of fecal constituents must be interpreted with great caution, since the constituents in question may be handled in the same nonideal fashion as the internal standard.

References

  1. J Nutr. 1951 Jan;43(1):77-85 - PubMed
  2. J Clin Invest. 1957 Jul;36(7):1183-92 - PubMed
  3. Biochem J. 1947;41(2):269-73 - PubMed
  4. Circulation. 1964 May;29:713-20 - PubMed
  5. N Engl J Med. 1967 Feb 2;276(5):273-81 concl - PubMed
  6. J Clin Invest. 1966 Sep;45(9):1503-15 - PubMed
  7. J Clin Invest. 1960 Jun;39:854-63 - PubMed
  8. Science. 1952 Dec 5;116(3023):634-5 - PubMed
  9. J Lipid Res. 1965 Jul;6:411-24 - PubMed
  10. Am J Dig Dis. 1957 Nov;2(11):628-42 - PubMed
  11. Acta Physiol Scand. 1956 Dec 31;38(2):121-8 - PubMed
  12. Am J Clin Nutr. 1954 Sep-Oct;2(5):336-42 - PubMed

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