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Oprica C, Emtestam L, Lapins J, et al. Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm. Anaerobe. 2004;10(3):155-64doi: 10.1016/j.anaerobe.2004.02.002.
Oprica, C., Emtestam, L., Lapins, J., Borglund, E., Nyberg, F., Stenlund, K., Lundeberg, L., Sillerström, E., & Nord, C. E. (2004). Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm. Anaerobe, 10(3), 155-64. https://doi.org/10.1016/j.anaerobe.2004.02.002
Oprica, Cristina, et al. "Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm." Anaerobe vol. 10,3 (2004): 155-64. doi: https://doi.org/10.1016/j.anaerobe.2004.02.002
Oprica C, Emtestam L, Lapins J, Borglund E, Nyberg F, Stenlund K, Lundeberg L, Sillerström E, Nord CE. Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm. Anaerobe. 2004 Jun;10(3):155-64. doi: 10.1016/j.anaerobe.2004.02.002. PMID: 16701513.
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Anaerobe. 2004 Jun;10(3):155-64. doi: 10.1016/j.anaerobe.2004.02.002.

Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm.

Anaerobe

Cristina Oprica, Lennart Emtestam, Jan Lapins, Erik Borglund, Filippa Nyberg, Kajsa Stenlund, Lena Lundeberg, Eva Sillerström, Carl Erik Nord

Affiliations

  1. Division of Clinical Bacteriology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-14186 Stockholm, Sweden.

PMID: 16701513 DOI: 10.1016/j.anaerobe.2004.02.002

Abstract

The objective was to study the prevalence and antibiotic susceptibility patterns of Propionibacterium acnes strains isolated from patients with moderate to severe acne in Stockholm, Sweden and to determine the diversity of pulsed-field gel electrophoresis types among resistant P. acnes strains. One hundred antibiotic-treated patients and 30 non-antibiotic-treated patients with moderate to severe acne participated in the investigation. Facial, neck and trunk skin samples were taken with the agar gel technique. The susceptibility of P. acnes strains to tetracycline, erythromycin, clindamycin and trimethoprim-sulfamethoxazole was determined by the agar dilution method. The genomic profiles of the resistant strains were determined by pulsed-field gel electrophoresis. In the group of patients treated with antibiotics, resistant P. acnes strains were recovered in 37%, while in the non-antibiotic group of patients the incidence of resistant strains was 13%. Thus antibiotic-resistant P. acnes strains were significantly more often isolated from antibiotic-treated patients with moderate to severe acne than from non-antibiotic-treated patients (odds ratio, 3.8; P=0.01). There was a genetic diversity among the P. acnes strains. Forty-four different patterns of SpeI DNA digests were detected and two predominant clones were found. P. acnes strains exhibited different antibiotic susceptibility patterns and identical genotypes or vice versa. A person can be colonized with different strains with varying degrees of antibiotic resistance. The risk of increased resistance of P. acnes must be considered when treating acne patients with antibiotics, and especially long-term therapy should be avoided.

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