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Haraldsson G, Meurman JH, Könönen E, et al. Properties of hemagglutination by Prevotella melaninogenica. Anaerobe. 2005;11(5):285-9doi: 10.1016/j.anaerobe.2005.02.004.
Haraldsson, G., Meurman, J. H., Könönen, E., & Holbrook, W. P. (2005). Properties of hemagglutination by Prevotella melaninogenica. Anaerobe, 11(5), 285-9. https://doi.org/10.1016/j.anaerobe.2005.02.004
Haraldsson, Gunnsteinn, et al. "Properties of hemagglutination by Prevotella melaninogenica." Anaerobe vol. 11,5 (2005): 285-9. doi: https://doi.org/10.1016/j.anaerobe.2005.02.004
Haraldsson G, Meurman JH, Könönen E, Holbrook WP. Properties of hemagglutination by Prevotella melaninogenica. Anaerobe. 2005 Oct;11(5):285-9. doi: 10.1016/j.anaerobe.2005.02.004. Epub 2005 Apr 26. PMID: 16701585.
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Anaerobe. 2005 Oct;11(5):285-9. doi: 10.1016/j.anaerobe.2005.02.004. Epub 2005 Apr 26.

Properties of hemagglutination by Prevotella melaninogenica.

Anaerobe

Gunnsteinn Haraldsson, Jukka H Meurman, Eija Könönen, W Peter Holbrook

Affiliations

  1. Faculty of Odontology, University of Iceland, Reykjavík, Iceland. [email protected]

PMID: 16701585 DOI: 10.1016/j.anaerobe.2005.02.004

Abstract

Although Prevotella melaninogenica belongs to the commensal oral microbiota, some strains possess putative virulence factors. For example, we have previously described fimbriated, hemagglutinating strains of P. melaninogenica, isolated from patients with periodontal disease. The aim of this investigation was to compare some chemical and physical properties of hemagglutination (HA) of P. melaninogenica with those of other pigmented gram-negative anaerobes. HA of 13 P. melaninogenica strains proved to be considerably weaker than that of the major periodontal pathogen, Porphyromonas gingivalis. Vigorous shaking reduced HA of shaken cells but the shaken supernatant had the same hemagglutinating activity as non-shaken cells. The hemagglutinating agent on P. melaninogenica seemed to be a protein, which can be separated from the cell and binds to lactose-, galactose-, and raffinose-containing carbohydrates on the erythrocytes. Adherence to epithelial cells did not differ significantly between the hemagglutinating and non-hemagglutinating strains of P. melaninogenica. Although P. melaninogenica is able to agglutinate erythrocytes, this potential virulence factor is of a considerably lower magnitude than that of major periodontal pathogens.

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