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Mönkemüller K, Fry LC, Rickes S, et al. Whipple's Disease. Curr Infect Dis Rep. 2006;8(2):96-102doi: 10.1007/s11908-006-0004-x.
Mönkemüller, K., Fry, L. C., Rickes, S., & Malfertheiner, P. (2006). Whipple's Disease. Current infectious disease reports, 8(2), 96-102. https://doi.org/10.1007/s11908-006-0004-x
Mönkemüller, Klaus, et al. "Whipple's Disease." Current infectious disease reports vol. 8,2 (2006): 96-102. doi: https://doi.org/10.1007/s11908-006-0004-x
Mönkemüller K, Fry LC, Rickes S, Malfertheiner P. Whipple's Disease. Curr Infect Dis Rep. 2006 Mar;8(2):96-102. doi: 10.1007/s11908-006-0004-x. PMID: 16524545.
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Curr Infect Dis Rep. 2006 Mar;8(2):96-102. doi: 10.1007/s11908-006-0004-x.

Whipple's Disease.

Current infectious disease reports

Klaus Mönkemüller, Lucía C Fry, Steffen Rickes, Peter Malfertheiner

Affiliations

  1. Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany. [email protected]

PMID: 16524545 DOI: 10.1007/s11908-006-0004-x

Abstract

Whipple's disease (WD) is a chronic debilitating disease caused by the bacillus Tropheryma whippleii. WD classically presents with the main clinical symptoms of polyarthralgias, chronic diarrhea, weight loss, and abdominal pain. Given its systemic involvement, it is common for WD to present with a multitude of other clinical scenarios--sometimes with predominant neurologic, cardiac, and dermatologic manifestations. WD can occur at any age, but it generally occurs during the fifth decade and predominantly in men. The diagnosis of WD is established by demonstrating the organism on biopsies from the involved system, by histology, electron microscopy, polymerase chain reaction, and more recently, by culture of bacteria. The histologic features include a coarse granular cytoplasm and foamy macrophages that stain strongly with the period-acid Schiff reagent. Current therapy includes an initial 2-week course of intravenous cephalosporins followed by 1-year oral trimethoprim-sulfamethoxazole.

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