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Guze LB, Hubert EG, Kalmanson GM. Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence. Infect Immun. 1970;1(6):532-7doi: 10.1128/iai.1.6.532-537.1970.
Guze, L. B., Hubert, E. G., & Kalmanson, G. M. (1970). Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence. Infection and immunity, 1(6), 532-7. https://doi.org/10.1128/iai.1.6.532-537.1970
Guze, L B, et al. "Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence." Infection and immunity vol. 1,6 (1970): 532-7. doi: https://doi.org/10.1128/iai.1.6.532-537.1970
Guze LB, Hubert EG, Kalmanson GM. Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence. Infect Immun. 1970 Jun;1(6):532-7. doi: 10.1128/iai.1.6.532-537.1970. PMID: 16557772; PMCID: PMC415938.
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Infect Immun. 1970 Jun;1(6):532-7. doi: 10.1128/iai.1.6.532-537.1970.

Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence.

Infection and immunity

L B Guze, E G Hubert, G M Kalmanson

Affiliations

  1. Veterans Administration Center, Los Angeles, California 90073.

PMID: 16557772 PMCID: PMC415938 DOI: 10.1128/iai.1.6.532-537.1970

Abstract

Rapidly growing Streptococcus faecalis was found to be markedly susceptible to the bactericidal activity of normal rat and rabbit sera, whereas stationary-phase organisms were resistant. In contrast, human serum killed neither phase organism. Further, human serum was found to interfere with killing by rabbit serum. The serosusceptible, rapidly growing organisms were less virulent than the seroresistant, stationary-phase organisms. This was tested by production of pyelonephritis in the rat after intravenous inoculation of the organism. Renal bacterial content over a period of 4 weeks was significantly less in those animals which had received rapidly growing organisms.

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