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Centifanto YM, Kaufman HE. Secretory immunoglobulin a and herpes keratitis. Infect Immun. 1970;2(6):778-82doi: 10.1128/iai.2.6.778-782.1970.
Centifanto, Y. M., & Kaufman, H. E. (1970). Secretory immunoglobulin a and herpes keratitis. Infection and immunity, 2(6), 778-82. https://doi.org/10.1128/iai.2.6.778-782.1970
Centifanto, Y M, and Kaufman, H E. "Secretory immunoglobulin a and herpes keratitis." Infection and immunity vol. 2,6 (1970): 778-82. doi: https://doi.org/10.1128/iai.2.6.778-782.1970
Centifanto YM, Kaufman HE. Secretory immunoglobulin a and herpes keratitis. Infect Immun. 1970 Dec;2(6):778-82. doi: 10.1128/iai.2.6.778-782.1970. PMID: 16557916; PMCID: PMC416091.
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Infect Immun. 1970 Dec;2(6):778-82. doi: 10.1128/iai.2.6.778-782.1970.

Secretory immunoglobulin a and herpes keratitis.

Infection and immunity

Y M Centifanto, H E Kaufman

Affiliations

  1. Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida 32601.

PMID: 16557916 PMCID: PMC416091 DOI: 10.1128/iai.2.6.778-782.1970

Abstract

The sensitization of herpes simplex virus by immunoglobulin G (IgG) antibodies was studied. Although herpes simplex virus sensitized by IgG could not be neutralized by IgA antibodies known to neutralize a similar number of unsensitized viruses, this protection could be overcome by larger amounts of IgA antibodies. This suggests that the effective neutralization of herpes simplex virus in ocular tissue is dependent on the relative concentrations of IgA and IgG antibodies. In vivo sensitized virus was isolated from chronically infected animals, and this may be the mechanism by which herpes simplex virus persists in animals with high titers of circulating antibodies in their serum.

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