Display options
Cite
Eaton MD, Farnham AE, Levinthal JD, et al. CYTOPATHIC EFFECT OF THE ATYPICAL PNEUMONIA ORGANISM IN CULTURES OF HUMAN TISSUE. J Bacteriol. 1962;84(6):1330-7doi: 10.1128/jb.84.6.1330-1337.1962.
Eaton, M. D., Farnham, A. E., Levinthal, J. D., & Scala, A. R. (1962). CYTOPATHIC EFFECT OF THE ATYPICAL PNEUMONIA ORGANISM IN CULTURES OF HUMAN TISSUE. Journal of bacteriology, 84(6), 1330-7. https://doi.org/10.1128/jb.84.6.1330-1337.1962
Eaton, M D, et al. "CYTOPATHIC EFFECT OF THE ATYPICAL PNEUMONIA ORGANISM IN CULTURES OF HUMAN TISSUE." Journal of bacteriology vol. 84,6 (1962): 1330-7. doi: https://doi.org/10.1128/jb.84.6.1330-1337.1962
Eaton MD, Farnham AE, Levinthal JD, Scala AR. CYTOPATHIC EFFECT OF THE ATYPICAL PNEUMONIA ORGANISM IN CULTURES OF HUMAN TISSUE. J Bacteriol. 1962 Dec;84(6):1330-7. doi: 10.1128/jb.84.6.1330-1337.1962. PMID: 16561984; PMCID: PMC278067.
Copy Download .nbib Format: NLM
Share it on

J Bacteriol. 1962 Dec;84(6):1330-7. doi: 10.1128/jb.84.6.1330-1337.1962.

CYTOPATHIC EFFECT OF THE ATYPICAL PNEUMONIA ORGANISM IN CULTURES OF HUMAN TISSUE.

Journal of bacteriology

M D Eaton, A E Farnham, J D Levinthal, A R Scala

Affiliations

  1. Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts.

PMID: 16561984 PMCID: PMC278067 DOI: 10.1128/jb.84.6.1330-1337.1962

Abstract

Eaton, Monroe D. (Harvard Medical School, Boston, Mass.), Ann E. Farnham, Jeana D. Levinthal, and Anthony R. Scala. Cytopathic effect of the atypical pneumonia organism in cultures of human tissue. J. Bacteriol. 84:1330-1337. 1962.-Three strains of the atypical pneumonia agent were adapted to grow in continuous cell cultures of human amnion or human embryonic lung, with production of initial increased acidity followed by destruction of the cells. Evidence is presented that cytopathic effects of the organism were associated with intracellular growth and formation of microcolonies. Clumps of organisms stained specifically with fluorescein-labeled antibody, and showed distinctive tinctorial reactions with the May Grünwald-Giemsa stain. The cytopathic effect was prevented by fresh serum from a rabbit immunized with an egg-passage strain of the atypical pneumonia agent. Heating the immune serum to 56 C for 30 min abolished the neutralizing effect. The significance of heat-labile serum constituents in killing or inhibition of mycoplasma is discussed.

References

  1. J Pathol Bacteriol. 1954 Jul;68(1):23-30 - PubMed
  2. J Gen Microbiol. 1956 Jul;14(3):763-74 - PubMed
  3. J Bacteriol. 1957 Feb;73(2):162-71 - PubMed
  4. J Exp Med. 1957 Oct 1;106(4):455-66 - PubMed
  5. J Bacteriol. 1957 Dec;74(6):784-7 - PubMed
  6. J Bacteriol. 1961 Apr;81:626-35 - PubMed
  7. Proc Soc Exp Biol Med. 1960 Nov;105:371-5 - PubMed
  8. Proc Soc Exp Biol Med. 1960 Nov;105:375-7 - PubMed
  9. J Exp Med. 1961 Jan 1;113:111-23 - PubMed
  10. Nature. 1961 Jan 21;189:247-8 - PubMed
  11. J Bacteriol. 1960 Feb;79:267-76 - PubMed
  12. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41-9 - PubMed
  13. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:715-8 - PubMed
  14. Ann N Y Acad Sci. 1960 Jan 15;79:433-49 - PubMed

Publication Types