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Neadle DJ, Pollitt RJ. The formation of 1-dimethylaminonaphthalene-5-sulphonamide during the preparation of 1-dimethylaminonaphthalene-5-sulphonylamino acids. Biochem J. 1965;97(2):607-8doi: 10.1042/bj0970607.
Neadle, D. J., & Pollitt, R. J. (1965). The formation of 1-dimethylaminonaphthalene-5-sulphonamide during the preparation of 1-dimethylaminonaphthalene-5-sulphonylamino acids. The Biochemical journal, 97(2), 607-8. https://doi.org/10.1042/bj0970607
Neadle, D J, and Pollitt, R J. "The formation of 1-dimethylaminonaphthalene-5-sulphonamide during the preparation of 1-dimethylaminonaphthalene-5-sulphonylamino acids." The Biochemical journal vol. 97,2 (1965): 607-8. doi: https://doi.org/10.1042/bj0970607
Neadle DJ, Pollitt RJ. The formation of 1-dimethylaminonaphthalene-5-sulphonamide during the preparation of 1-dimethylaminonaphthalene-5-sulphonylamino acids. Biochem J. 1965 Nov;97(2):607-8. doi: 10.1042/bj0970607. PMID: 16749171; PMCID: PMC1264682.
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Biochem J. 1965 Nov;97(2):607-8. doi: 10.1042/bj0970607.

The formation of 1-dimethylaminonaphthalene-5-sulphonamide during the preparation of 1-dimethylaminonaphthalene-5-sulphonylamino acids.

The Biochemical journal

D J Neadle, R J Pollitt

Affiliations

  1. Medical Research Council Unit for Research on the Chemical Pathology of Mental Disorders, Department of Physiology, The Medical School, Birmingham 15.

PMID: 16749171 PMCID: PMC1264682 DOI: 10.1042/bj0970607

Abstract

1. The amount of 1-dimethylaminonaphthalene-5-sulphonamide formed during the reaction of an amino acid with 1-dimethylaminonaphthalene-5-sulphonyl chloride depends on the structure of the amino acid and on the conditions used. 2. The reaction probably involves attack of a further molecule of 1-dimethylaminonaphthalene-5-sulphonyl chloride on the 1-dimethylaminonaphthalene-5-sulphonyl-amino acid and also gives the aldehyde (or ketone) with one carbon atom less than the parent amino acid.

References

  1. Biochem J. 1963 Nov;89:379-80 - PubMed
  2. Experientia. 1964 Oct 15;20(10):559-60 - PubMed

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