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Org Lett. 2006 Jul 20;8(15):3387-90. doi: 10.1021/ol061384m.

Palladium-catalyzed oxidation of Boc-protected N-methylamines with IOAc as the oxidant: a Boc-directed sp3 C-H bond activation.

Organic letters

Dong-Hui Wang, Xue-Shi Hao, Di-Fu Wu, Jin-Quan Yu

Affiliations

  1. Department of Chemistry MS015, Brandeis University, Waltham, Massachusetts 02454-9110, USA.

PMID: 16836412 DOI: 10.1021/ol061384m

Abstract

[Structure: see text] Pd-catalyzed selective oxidation of Boc-protected N-methylamines with IOAc as the oxidant is described. Evidence for the involvement of a Boc-directed C-H activation process is provided.

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