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McIntosh SJ, Watson ID, Hughes PW, et al. Off-line automated sample preparation--experience in a clinical drug investigation unit. J Pharm Biomed Anal. 1987;5(4):353-60doi: 10.1016/0731-7085(87)80041-9.
McIntosh, S. J., Watson, I. D., Hughes, P. W., Chambers, A. M., & Stewart, M. J. (1987). Off-line automated sample preparation--experience in a clinical drug investigation unit. Journal of pharmaceutical and biomedical analysis, 5(4), 353-60. https://doi.org/10.1016/0731-7085(87)80041-9
McIntosh, S J, et al. "Off-line automated sample preparation--experience in a clinical drug investigation unit." Journal of pharmaceutical and biomedical analysis vol. 5,4 (1987): 353-60. doi: https://doi.org/10.1016/0731-7085(87)80041-9
McIntosh SJ, Watson ID, Hughes PW, Chambers AM, Stewart MJ. Off-line automated sample preparation--experience in a clinical drug investigation unit. J Pharm Biomed Anal. 1987;5(4):353-60. doi: 10.1016/0731-7085(87)80041-9. PMID: 16867504.
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J Pharm Biomed Anal. 1987;5(4):353-60. doi: 10.1016/0731-7085(87)80041-9.

Off-line automated sample preparation--experience in a clinical drug investigation unit.

Journal of pharmaceutical and biomedical analysis

S J McIntosh, I D Watson, P W Hughes, A M Chambers, M J Stewart

Affiliations

  1. Drug Investigation Unit, Department of Biochemistry, Royal Infirmary, Glasgow G4 0SF, UK.

PMID: 16867504 DOI: 10.1016/0731-7085(87)80041-9

Abstract

The authors describe an evaluation of the Du Pont Prep. off-line automatic centrifugal sample processing system, used in the authors' Drug Investigation Unit over the past two years. In comparison to liquid-liquid extraction, the authors found that assay precision has generally been improved, absolute recovery was quantitative, reliability has been good and the use of the system has resulted in notable labour saving. However, the cost per test based on a seven-year amortization of capital cost shows that the system is more expensive. Assays for urinary opiates, serum tricyclic antidepressants, serum isoxicam, serum valproate, serum metoclopramide and serum pindolol are presented and the merits of the method are compared with those for manual liquid-liquid extraction procedures.

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