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Zommer-Urbańska S, Bojarowicz H. Spectrophotometric investigations on protolytic equilibria of mefenamic acid and determination by means of Fe(III) in methanol-aqueous media. J Pharm Biomed Anal. 1986;4(4):475-81doi: 10.1016/0731-7085(86)80068-1.
Zommer-Urbańska, S., & Bojarowicz, H. (1986). Spectrophotometric investigations on protolytic equilibria of mefenamic acid and determination by means of Fe(III) in methanol-aqueous media. Journal of pharmaceutical and biomedical analysis, 4(4), 475-81. https://doi.org/10.1016/0731-7085(86)80068-1
Zommer-Urbańska, S, and Bojarowicz, H. "Spectrophotometric investigations on protolytic equilibria of mefenamic acid and determination by means of Fe(III) in methanol-aqueous media." Journal of pharmaceutical and biomedical analysis vol. 4,4 (1986): 475-81. doi: https://doi.org/10.1016/0731-7085(86)80068-1
Zommer-Urbańska S, Bojarowicz H. Spectrophotometric investigations on protolytic equilibria of mefenamic acid and determination by means of Fe(III) in methanol-aqueous media. J Pharm Biomed Anal. 1986;4(4):475-81. doi: 10.1016/0731-7085(86)80068-1. PMID: 16867583.
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J Pharm Biomed Anal. 1986;4(4):475-81. doi: 10.1016/0731-7085(86)80068-1.

Spectrophotometric investigations on protolytic equilibria of mefenamic acid and determination by means of Fe(III) in methanol-aqueous media.

Journal of pharmaceutical and biomedical analysis

S Zommer-Urbańska, H Bojarowicz

Affiliations

  1. Department of Pharmaceutical Analysis, Medical Centre of Postgraduate Education, Debowa 3, 85-626 Bydgoszcz, Poland.

PMID: 16867583 DOI: 10.1016/0731-7085(86)80068-1

Abstract

Studies have been carried out on the effect of pH (from pH 11.33 to H(O) = -4.65) on the UV spectrum of mefenamic acid. The dissociation constant pKa was found to be 4.55 +/- 0.06 and the protonation constant pK(2) was -1.78 +/- 0.18 in methanol-aqueous media. Mefenamic acid was determined spectrophotometrically by formation of a coloured complex (2:5) with Fe(III). At 495 nm Beer's law was followed for the concentration range 96.52 to 579.12 mug ml(-1).

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