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Hansen SH, Pedersen SB. Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: application in pharmacokinetics. J Pharm Biomed Anal. 1986;4(1):69-82doi: 10.1016/0731-7085(86)80025-5.
Hansen, S. H., & Pedersen, S. B. (1986). Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: application in pharmacokinetics. Journal of pharmaceutical and biomedical analysis, 4(1), 69-82. https://doi.org/10.1016/0731-7085(86)80025-5
Hansen, S H, and Pedersen, S B. "Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: application in pharmacokinetics." Journal of pharmaceutical and biomedical analysis vol. 4,1 (1986): 69-82. doi: https://doi.org/10.1016/0731-7085(86)80025-5
Hansen SH, Pedersen SB. Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: application in pharmacokinetics. J Pharm Biomed Anal. 1986;4(1):69-82. doi: 10.1016/0731-7085(86)80025-5. PMID: 16867632.
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J Pharm Biomed Anal. 1986;4(1):69-82. doi: 10.1016/0731-7085(86)80025-5.

Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: application in pharmacokinetics.

Journal of pharmaceutical and biomedical analysis

S H Hansen, S B Pedersen

Affiliations

  1. Department of Organic Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK-2100 Copenhagen, Denmark.

PMID: 16867632 DOI: 10.1016/0731-7085(86)80025-5

Abstract

An LC method able to separate all known metabolites of tolfenamic acid was developed. It was applied to characterize the metabolic profiles after single and multiple peroral doses of tolfenamic acid to volunteers. Up to 80% of the dose, mostly conjugated metabolites, could be recovered in the urine by this method. Two of the metabolites showed plasma half-lives of several days and peculiar conjugation properties.

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