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J Pharm Biomed Anal. 1984;2(2):197-205. doi: 10.1016/0731-7085(84)80071-0.

Enrichment techniques and trace analysis with microbore columns in liquid chromatography.

Journal of pharmaceutical and biomedical analysis

M Krejci, K Slais, D Kourilová, M Vespalcová

Affiliations

  1. Institute of Analytical Chemistry, Czechoslovak Academy of Sciences, 611 42 Brno, Czechoslovakia.

PMID: 16867748 DOI: 10.1016/0731-7085(84)80071-0

Abstract

The advantages of microbore columns for trace analysis by liquid chromatography are identified, with reference to on-column enrichment techniques performed on analytical micro-columns. The selectivity and high sensitivity of the amperometric detector are utilized in combination with a microbore column for a number of pharmaceutical and bioanalytical analyses, including phenothiazines, parabens, sulphonamides, catecholamines, tetracyclines, vitamins, amino acids and dipeptides.

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