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Petit J, Fouin-Fortunet H, Colomb V, et al. Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate. Clin Nutr. 1991;10(6):328-35doi: 10.1016/0261-5614(91)90062-h.
Petit, J., Fouin-Fortunet, H., Colomb, V., Hecketsweiler, B., Lemeland, J. F., Denis, P., & Colin, R. (1991). Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate. Clinical nutrition (Edinburgh, Scotland), 10(6), 328-35. https://doi.org/10.1016/0261-5614(91)90062-h
Petit, J, et al. "Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate." Clinical nutrition (Edinburgh, Scotland) vol. 10,6 (1991): 328-35. doi: https://doi.org/10.1016/0261-5614(91)90062-h
Petit J, Fouin-Fortunet H, Colomb V, Hecketsweiler B, Lemeland JF, Denis P, Colin R. Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate. Clin Nutr. 1991 Dec;10(6):328-35. doi: 10.1016/0261-5614(91)90062-h. PMID: 16839940.
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Clin Nutr. 1991 Dec;10(6):328-35. doi: 10.1016/0261-5614(91)90062-h.

Liver factors involved in drug metabolism in experimentally infected rats: deleterious effect of ornithine alpha-ketoisocaproate.

Clinical nutrition (Edinburgh, Scotland)

J Petit, H Fouin-Fortunet, V Colomb, B Hecketsweiler, J F Lemeland, P Denis, R Colin

Affiliations

  1. Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle Hôpital Charles Nicolle, 76031 Rouen-Cédex, France.

PMID: 16839940 DOI: 10.1016/0261-5614(91)90062-h

Abstract

This study was designed to determine the effect of ornithine alpha-ketoisocaproate (O-KIC), a compound reducing muscle protein breakdown in physiological conditions, on liver factors involved in drug metabolism in rats with acute retrograde pyelonephritis. 91 rats were assigned to 7 groups differing in the level of food intake, induced infection, and the treatment by O-KIC (168 mg/kg bw/day). Rats were killed on the third day. O-KIC increased nitrogen balance and weight gain in controls, but not in malnourished infected or non-infected rats. Liver glutathione was significantly reduced by O-KIC in malnourished infected and non-infected rats. Though O-KIC induced a rise in liver microsomal proteins in control and infected animals, it decreased cytochrome P-450 in controls, and aminopyrine demethylase in both control and infected groups.

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