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Small NV, Europe-Firmer GN, Newell PC. Calcium induces cyclic GMP formation in Dictyostelium. FEBS Lett. 1986;203(1):11-4doi: 10.1016/0014-5793(86)81426-0.
Small, N. V., Europe-Firmer, G. N., & Newell, P. C. (1986). Calcium induces cyclic GMP formation in Dictyostelium. FEBS letters, 203(1), 11-4. https://doi.org/10.1016/0014-5793(86)81426-0
Small, N V, et al. "Calcium induces cyclic GMP formation in Dictyostelium." FEBS letters vol. 203,1 (1986): 11-4. doi: https://doi.org/10.1016/0014-5793(86)81426-0
Small NV, Europe-Firmer GN, Newell PC. Calcium induces cyclic GMP formation in Dictyostelium. FEBS Lett. 1986 Jul 14;203(1):11-4. doi: 10.1016/0014-5793(86)81426-0. PMID: 16926128.
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FEBS Lett. 1986 Jul 14;203(1):11-4. doi: 10.1016/0014-5793(86)81426-0.

Calcium induces cyclic GMP formation in Dictyostelium.

FEBS letters

N V Small, G N Europe-Firmer, P C Newell

Affiliations

  1. Department of Biochemistry, South Parks Road, Oxford 0X1 3QU, England.

PMID: 16926128 DOI: 10.1016/0014-5793(86)81426-0

Abstract

Cyclic GMP is rapidly formed a few seconds after binding of chemotactic signalling molecules to specific receptors on the cell surface of Dictyostelium amoebae. This phenomenon could be mimicked by addition of a pulse of Ca2+ to permeabilised amoebae. The concentration of Ca2+ for half-maximal response was 60 microM. Other ions (K+, Na+, Mg+ or Mn+) had no effect. A pulse of 5 microM IP3 produced a cyclic GMP response of similar magnitude but IP2 elicited no response. The data provide strong support for the hypothesis that cell surface receptor binding induces cyclic GMP formation by liberating Ca2+ from internal stores.

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