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Eriksson LS, Björkman O. Influence of insulin on peripheral uptake of branched chain amino acids in the 60-hour fasted state. Clin Nutr. 1993;12(4):217-22doi: 10.1016/0261-5614(93)90018-y.
Eriksson, L. S., & Björkman, O. (1993). Influence of insulin on peripheral uptake of branched chain amino acids in the 60-hour fasted state. Clinical nutrition (Edinburgh, Scotland), 12(4), 217-22. https://doi.org/10.1016/0261-5614(93)90018-y
Eriksson, L S, and Björkman, O. "Influence of insulin on peripheral uptake of branched chain amino acids in the 60-hour fasted state." Clinical nutrition (Edinburgh, Scotland) vol. 12,4 (1993): 217-22. doi: https://doi.org/10.1016/0261-5614(93)90018-y
Eriksson LS, Björkman O. Influence of insulin on peripheral uptake of branched chain amino acids in the 60-hour fasted state. Clin Nutr. 1993 Aug;12(4):217-22. doi: 10.1016/0261-5614(93)90018-y. PMID: 16843315.
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Clin Nutr. 1993 Aug;12(4):217-22. doi: 10.1016/0261-5614(93)90018-y.

Influence of insulin on peripheral uptake of branched chain amino acids in the 60-hour fasted state.

Clinical nutrition (Edinburgh, Scotland)

L S Eriksson, O Björkman

Affiliations

  1. Department of Medicine, Huddinge Hospital, Karolinska Institute, S-14186 Huddinge, Sweden.

PMID: 16843315 DOI: 10.1016/0261-5614(93)90018-y

Abstract

The influence of insulin on branched chain amino acid (BCAA) metabolism was investigated in healthy subjects faster for 60-64 h, using the euglycemic insulin clamp technique and hepatic venous catheterization. As compared to the postabsorptive state, fasting resulted in a 50-80% decrease in glucose disposal during the clamps, indicating insulin resistance. However, the arterial concentrations of BCAA, which were increased by 200-220% after the fast, decreased to a similar extent during hyperinsulinemia, regardless of the fasting situation. The splanchnic exchange of BCAA was unaltered both in response to fasting itself and to fasting and hyperinsulinemia. The results suggest that insulin resistance during fasting does not influence BCAA metabolism. Furthermore, the changes in BCAA concentrations after a prolonged fast are due to altered peripheral metabolism of BCAA.

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