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Beau P, Meyran E, Chassin J, et al. Cyclic parenteral nutrition in hospitalized adult patients: a 9-year experience. Clin Nutr. 1994;13(1):22-8doi: 10.1016/0261-5614(94)90006-x.
Beau, P., Meyran, E., Chassin, J., & Matuchansky, C. (1994). Cyclic parenteral nutrition in hospitalized adult patients: a 9-year experience. Clinical nutrition (Edinburgh, Scotland), 13(1), 22-8. https://doi.org/10.1016/0261-5614(94)90006-x
Beau, P, et al. "Cyclic parenteral nutrition in hospitalized adult patients: a 9-year experience." Clinical nutrition (Edinburgh, Scotland) vol. 13,1 (1994): 22-8. doi: https://doi.org/10.1016/0261-5614(94)90006-x
Beau P, Meyran E, Chassin J, Matuchansky C. Cyclic parenteral nutrition in hospitalized adult patients: a 9-year experience. Clin Nutr. 1994 Feb;13(1):22-8. doi: 10.1016/0261-5614(94)90006-x. PMID: 16843348.
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Clin Nutr. 1994 Feb;13(1):22-8. doi: 10.1016/0261-5614(94)90006-x.

Cyclic parenteral nutrition in hospitalized adult patients: a 9-year experience.

Clinical nutrition (Edinburgh, Scotland)

P Beau, E Meyran, J Chassin, C Matuchansky

Affiliations

  1. Gastroenterology and Nutritional Support Unit, University Hospital, La Milétrie, 86021 Poitiers, France.

PMID: 16843348 DOI: 10.1016/0261-5614(94)90006-x

Abstract

We are reporting our 9-year experience of cyclic parenteral nutrition with 200 in-patients (mean age 52 years) treated 64 +/- (SEM)3 days (range: 15-230) for Gl diseases. During the first period (A, n = 38), all-in-one nutritive bags with intralipid 10% were used; in a second period (B, n = 135), intralipid 10% was infused separately over the first 6 h of nutrition; in the final period (C, n = 27), Intralipid 20% was used in all-in-one nutritive bags. Indications for parenteral nutrition were non-malignant digestive diseases in 89.5% of the cases. The frequency of complications appearing during cyclic parenteral nutrition was the following: catheter-related sepsis 8%, catheter obstruction 8%, hypertriglyceridemia 33%, hypercholesterolemia 14.7%, liver function test abnormalities 28% and biliary sludge and/or lithiasis 31.6%. 5 patients, with chronic obstructive small bowel disease, developed jaundice with no identifiable cause other than parenteral nutrition. The prevalence of catheter obstruction significantly decreased (P < 0.01) during period B, as compared with periods A and C. The prevalence of liver function test abnormalities decreased significantly (P < 0.01) during periods B and C, as compared with period A. Mortality rate related to cyclic parenteral nutrition was 3%. These results suggest that a) the separate infusion of lipid emulsion reduces the prevalence of catheter obstruction; b) as compared with 10% intralipid in all-in-one nutritive bags, the separate infusion of 10% Intralipid or the 20% Intralipid given in all-in-one nutritive bags is associated with a decreased prevalence of liver function test abnormalities; c) chronic small intestine obstruction seems to play a key role in parenteral-associated jaundice.

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