Display options
Cite
Naber TH, Heymer F, Van Den Hamer CJ, et al. The in-vitro uptake of zinc by blood cells in rats with long-term inflammatory stress. Clin Nutr. 1994;13(4):247-55doi: 10.1016/0261-5614(94)90083-3.
Naber, T. H., Heymer, F., Van Den Hamer, C. J., Van Den Broek, W. J., & Jansen, J. B. (1994). The in-vitro uptake of zinc by blood cells in rats with long-term inflammatory stress. Clinical nutrition (Edinburgh, Scotland), 13(4), 247-55. https://doi.org/10.1016/0261-5614(94)90083-3
Naber, T H, et al. "The in-vitro uptake of zinc by blood cells in rats with long-term inflammatory stress." Clinical nutrition (Edinburgh, Scotland) vol. 13,4 (1994): 247-55. doi: https://doi.org/10.1016/0261-5614(94)90083-3
Naber TH, Heymer F, Van Den Hamer CJ, Van Den Broek WJ, Jansen JB. The in-vitro uptake of zinc by blood cells in rats with long-term inflammatory stress. Clin Nutr. 1994 Aug;13(4):247-55. doi: 10.1016/0261-5614(94)90083-3. PMID: 16843393.
Copy Download .nbib Format: NLM
Share it on

Clin Nutr. 1994 Aug;13(4):247-55. doi: 10.1016/0261-5614(94)90083-3.

The in-vitro uptake of zinc by blood cells in rats with long-term inflammatory stress.

Clinical nutrition (Edinburgh, Scotland)

T H Naber, F Heymer, C J Van Den Hamer, W J Van Den Broek, J B Jansen

Affiliations

  1. Department of Medicine, Division of Gastrointestinal and Liver Diseases, University Hospital Nijmegen, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands.

PMID: 16843393 DOI: 10.1016/0261-5614(94)90083-3

Abstract

The aim of the present study was to investigate the in vitro uptake of zinc by blood cells, in an attempt to distinguish between those conditions in which low plasma zinc concentrations are due to inflammatory stress, and those which are due to true zinc deficiency. Inflammation induced by intramuscular injection of turpentine caused a significant reduction in plasma albumin concentrations, which persisted until the end of the study (2 weeks). It also caused a reduction in the plasma zinc concentration which was most marked during the first few days. A smaller difference persisted until the end of the study. When the serum zinc concentration was corrected for the hypoalbuminaemia, the changes in serum zinc concentration after the first 4 days of turpentine were small and mainly non-significant. The in vitro uptake of zinc by erythrocytes obtained from animals with inflammation did not increase, whereas the uptake was increased in cells obtained from animals with true zinc deficiency. Therefore this study suggests a method that can probably differentiate between an apparent zinc deficiency due to inflammatory stress and a real zinc deficiency, but additional experiments to validate this method should be performed.

Publication Types