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Staun M, Tjellesen L, Thale M, et al. Bone mineral content in patients on home parenteral nutrition. Clin Nutr. 1994;13(6):351-5doi: 10.1016/0261-5614(94)90024-8.
Staun, M., Tjellesen, L., Thale, M., Rannem, T., Schaadt, O., & Jarnum, S. (1994). Bone mineral content in patients on home parenteral nutrition. Clinical nutrition (Edinburgh, Scotland), 13(6), 351-5. https://doi.org/10.1016/0261-5614(94)90024-8
Staun, M, et al. "Bone mineral content in patients on home parenteral nutrition." Clinical nutrition (Edinburgh, Scotland) vol. 13,6 (1994): 351-5. doi: https://doi.org/10.1016/0261-5614(94)90024-8
Staun M, Tjellesen L, Thale M, Rannem T, Schaadt O, Jarnum S. Bone mineral content in patients on home parenteral nutrition. Clin Nutr. 1994 Dec;13(6):351-5. doi: 10.1016/0261-5614(94)90024-8. PMID: 16843413.
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Clin Nutr. 1994 Dec;13(6):351-5. doi: 10.1016/0261-5614(94)90024-8.

Bone mineral content in patients on home parenteral nutrition.

Clinical nutrition (Edinburgh, Scotland)

M Staun, L Tjellesen, M Thale, T Rannem, O Schaadt, S Jarnum

Affiliations

  1. Department of Medicine A, Division of Gastroenterology, Rigshospitalet, DK-2100 Copenhagen, Denmark.

PMID: 16843413 DOI: 10.1016/0261-5614(94)90024-8

Abstract

Bone mineral content (BMC) was monitored in 15 patients with short bowel syndrome receiving home parenteral nutrition (HPN). Thirteen patients had Crohn's disease and 2 ulcerative colitis (mean age 36 years, range 23-69 years). During the study the patients received HPN for a mean period of 62 months, range 20-106 months. At the time of inclusion the patients had a significantly reduced BMC of lumbar spine and femoral neck compared to normals (Z-scores = -3.35 +/- 3.49, p < 0.05 and Z-score = -2.23 +/- 2.11, p < 0.05). During HPN the Z-score of lumbar spine BMC decreased in 8 patients and increased slightly or was unchanged in 7 patients. The mean Z-score of BMC of lumbar spine declined by 1.46 +/- 2.48 (p < 0.05) and the Z-score of femoral neck BMC declined by 0.831 +/- 1.14 (p < 0.05). This corresponds to a yearly decrease of lumbar spine BMC of 4%. There was no correlation between the decline in BMC during the study and the period of length the patients were on HPN. We conclude that patients on HPN have a low bone mineral density and that the bone loss continues during prolonged HPN.

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