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Gianotti L, Alexander JW, Eaves-Pyles T, et al. Dietary fatty acids modulate host bacteriocidal response,microbial translocation and survival following blood transfusion and thermal injury. Clin Nutr. 1996;15(6):291-6doi: 10.1016/s0261-5614(96)80002-1.
Gianotti, L., Alexander, J. W., Eaves-Pyles, T., & Fukushima, R. (1996). Dietary fatty acids modulate host bacteriocidal response,microbial translocation and survival following blood transfusion and thermal injury. Clinical nutrition (Edinburgh, Scotland), 15(6), 291-6. https://doi.org/10.1016/s0261-5614(96)80002-1
Gianotti, L, et al. "Dietary fatty acids modulate host bacteriocidal response,microbial translocation and survival following blood transfusion and thermal injury." Clinical nutrition (Edinburgh, Scotland) vol. 15,6 (1996): 291-6. doi: https://doi.org/10.1016/s0261-5614(96)80002-1
Gianotti L, Alexander JW, Eaves-Pyles T, Fukushima R. Dietary fatty acids modulate host bacteriocidal response,microbial translocation and survival following blood transfusion and thermal injury. Clin Nutr. 1996 Dec;15(6):291-6. doi: 10.1016/s0261-5614(96)80002-1. PMID: 16844059.
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Clin Nutr. 1996 Dec;15(6):291-6. doi: 10.1016/s0261-5614(96)80002-1.

Dietary fatty acids modulate host bacteriocidal response,microbial translocation and survival following blood transfusion and thermal injury.

Clinical nutrition (Edinburgh, Scotland)

L Gianotti, J W Alexander, T Eaves-Pyles, R Fukushima

Affiliations

  1. University of Cincinnati College of Medicine, Department of Surgery, Transplantation Division, and Shriners BurnsInstitute, Cincinnati, Ohio, USA.

PMID: 16844059 DOI: 10.1016/s0261-5614(96)80002-1

Abstract

The effect of dietary lipids on bacterial translocation, killing of translocated organisms and host survival was studied in a burned animal model. Balb/c mice were fed with one of the three experimental AIN-76A diets (containing 15% of energy from fish oil, safflower oil or a 50:50 mixture), AIN-76A without added lipids or a nonpurified stock diet. All animals were transfused on day 10. On day 15, the animals were gavaged with 10(10) 14C radiolabelled Escherichia coli and given a 20% burn injury. Survival was 84% in the fish oil group versus 36% in the safflower oil and 50:50 diet groups, and 25% and 20% in the two control groups (P < 0.0001). The numbers of viable translocating bacteria were reduced in all tested organs in the fish oil groups compared to the other groups. It is concluded that a diet enriched in fish oil has beneficial effects during gut-derived sepsis.

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