Display options
Cite
Palka YS, Sawyer CH. The effects of hypothalamic implants of ovarian steroids on oestrous behaviour in rabbits. J Physiol. 1966;185(2):251-69doi: 10.1113/jphysiol.1966.sp007986.
Palka, Y. S., & Sawyer, C. H. (1966). The effects of hypothalamic implants of ovarian steroids on oestrous behaviour in rabbits. The Journal of physiology, 185(2), 251-69. https://doi.org/10.1113/jphysiol.1966.sp007986
Palka, Y S, and Sawyer, C H. "The effects of hypothalamic implants of ovarian steroids on oestrous behaviour in rabbits." The Journal of physiology vol. 185,2 (1966): 251-69. doi: https://doi.org/10.1113/jphysiol.1966.sp007986
Palka YS, Sawyer CH. The effects of hypothalamic implants of ovarian steroids on oestrous behaviour in rabbits. J Physiol. 1966 Jul;185(2):251-69. doi: 10.1113/jphysiol.1966.sp007986. PMID: 16992222; PMCID: PMC1395822.
Copy Download .nbib Format: NLM
Share it on

J Physiol. 1966 Jul;185(2):251-69. doi: 10.1113/jphysiol.1966.sp007986.

The effects of hypothalamic implants of ovarian steroids on oestrous behaviour in rabbits.

The Journal of physiology

Y S Palka, C H Sawyer

PMID: 16992222 PMCID: PMC1395822 DOI: 10.1113/jphysiol.1966.sp007986

Abstract

1. The brains of ovariectomized female rabbits which were anoestrous in behaviour when tested with vigorous males were implanted either bilaterally or unilaterally with 10% oestradiol benzoate in cholestrol.2. Rabbits with implants in the ventromedial-premammillary hypothalamus ca. 1 mm lateral to the mid line became highly oestrous in behaviour within 1-2 days of implantation and mated 100% of the times tested. Implants of blank tubing, cholesterol or progesterone in this area, or oestrogen implants elsewhere in the hypothalamus had no effect on sexual behaviour.3. The uteri of all females implanted with diluted oestrogen were atrophic and similar to those of castrate controls, indicating that the effects of hypothalamic implants on sexual behaviour were direct local effects of oestrogen on the C.N.S.4. Rabbits implanted bilaterally with undiluted oestradiol benzoate showed some slight systemic spread of the implanted oestrogen. Oestrous behaviour was evoked within an average of 3.4 days by implantation into a large hypothalamic area, presumably as a result of oestrogen diffusing from the site of implantation to the critical ventromedial-premammillary region.5. Injections of progesterone in dosages known to block oestrous behaviour in intact or oestrogen-primed rabbits, failed to block this behaviour in females implanted with pure oestrogen in the ventromedial-premammillary hypothalamus.6. Implantation of progestins into the ventromedial-premammillary area in overiectomized rabbits did not usually inhibit oestrous behaviour induced by small threshold doses of systemically administered oestrogen. The possibilities that oestrogen and progesterone (1) interact in different areas of the C.N.S. or (2) compete for ;steroid receptors' in the ventromedial-premammillary hypothalamus are discussed.

References

  1. J Physiol. 1934 Dec 31;83(2):145-56 - PubMed
  2. Endocrinology. 1959 Oct;65:652-68 - PubMed
  3. Br Med Bull. 1965 Jan;21:87-90 - PubMed
  4. Science. 1956 Aug 3;124(3214):228-9 - PubMed
  5. Endocrinology. 1965 Apr;76:691-9 - PubMed
  6. Endocrinology. 1964 Aug;75:243-8 - PubMed
  7. J Physiol. 1964 Aug;172:383-92 - PubMed
  8. J Physiol. 1964 Jun;171:275-301 - PubMed
  9. J Physiol. 1964 Jun;171:254-74 - PubMed
  10. Nature. 1964 Apr 25;202:413-4 - PubMed
  11. Am J Physiol. 1963 Dec;205:1073-6 - PubMed
  12. J Reprod Fertil. 1963 Feb;5:23-40 - PubMed
  13. Am J Physiol. 1962 Sep;203:493-6 - PubMed
  14. Endocrinology. 1959 Oct;65:644-51 - PubMed
  15. J Exp Zool. 1959 Oct-Dec;142:227-46 - PubMed
  16. J Comp Physiol Psychol. 1961 Feb;54:72-7 - PubMed
  17. Acta Endocrinol (Copenh). 1961 Jul;37:385-93 - PubMed
  18. Science. 1958 Dec 26;128(3339):1626-7 - PubMed
  19. Endocrinology. 1958 Jun;62(6):790-7 - PubMed
  20. Ann Endocrinol (Paris). 1956 Nov-Dec;17(6):731-45 - PubMed
  21. J Comp Neurol. 1954 Dec;101(3):801-24 - PubMed

Publication Types