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E Silva MR, Sproull DH. An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord. J Physiol. 1966;185(2):445-54doi: 10.1113/jphysiol.1966.sp007995.
E Silva, M. R., & Sproull, D. H. (1966). An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord. The Journal of physiology, 185(2), 445-54. https://doi.org/10.1113/jphysiol.1966.sp007995
E Silva, M R, and Sproull, D H. "An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord." The Journal of physiology vol. 185,2 (1966): 445-54. doi: https://doi.org/10.1113/jphysiol.1966.sp007995
E Silva MR, Sproull DH. An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord. J Physiol. 1966 Jul;185(2):445-54. doi: 10.1113/jphysiol.1966.sp007995. PMID: 16992231; PMCID: PMC1395826.
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J Physiol. 1966 Jul;185(2):445-54. doi: 10.1113/jphysiol.1966.sp007995.

An excitatory action of adrenaline, noradrenaline, and 5-hydroxytryptamine on the spinal cord.

The Journal of physiology

M R E Silva, D H Sproull

PMID: 16992231 PMCID: PMC1395826 DOI: 10.1113/jphysiol.1966.sp007995

Abstract

1. Fasciculation was produced in the trapezius and sternomastoid muscles of anaesthetized cats by adrenaline, noradrenaline and 5-hydroxytryptamine (5-HT) put into the cisterna magna. Isoprenaline, similarly applied, was ineffective.2. Each of the three active amines was without effect when applied for a second time after the fasciculation in response to the first application had passed off, but 5-HT was effective after adrenaline and, similarly, adrenaline after 5-HT.3. Fasciculation produced by adrenaline, but not by 5-HT, was inhibited by ergotamine or phenoxybenzamine, given intravenously.4. In producing fasciculation, the adrenaline appeared to be acting on or through the lateral aspect of the upper cervical cord, about the line of emergence of the roots of the spinal accessory nerve, mainly in C1 and C2.5. The electromyograms of the fasciculation due to adrenaline and 5-HT showed intermittent bursts of activity. After adrenaline, the bursts consisted of fewer spikes than after 5-HT. The intervals between consecutive spikes were 3.75-5 msec after either amine, and the bursts occurred irregularly, at frequencies between 7 and 12/sec.6. It is suggested that adrenaline and 5-HT have excitatory actions on the dendrites or somata of the spinal accessory motor neurones, and the possible role of these amines as synaptic transmitters in the spinal nucleus of the accessory nerve is discussed.

References

  1. J Physiol. 1963 Dec;169:527-37 - PubMed
  2. Acta Physiol Scand. 1964 Jan-Feb;60:112-9 - PubMed
  3. J Physiol. 1964 Jun;171:494-503 - PubMed
  4. J Physiol. 1964 Sep;173:226-31 - PubMed
  5. J Physiol. 1949 Dec;110(3-4):319-29 - PubMed

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