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Rolf N. Central neuroaxis blockade and coronary circulation. Curr Opin Anaesthesiol. 1998;11(5):517-20doi: 10.1097/00001503-199810000-00012.
Rolf, N. (1998). Central neuroaxis blockade and coronary circulation. Current opinion in anaesthesiology, 11(5), 517-20. https://doi.org/10.1097/00001503-199810000-00012
Rolf, N. "Central neuroaxis blockade and coronary circulation." Current opinion in anaesthesiology vol. 11,5 (1998): 517-20. doi: https://doi.org/10.1097/00001503-199810000-00012
Rolf N. Central neuroaxis blockade and coronary circulation. Curr Opin Anaesthesiol. 1998 Oct;11(5):517-20. doi: 10.1097/00001503-199810000-00012. PMID: 17013267.
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Curr Opin Anaesthesiol. 1998 Oct;11(5):517-20. doi: 10.1097/00001503-199810000-00012.

Central neuroaxis blockade and coronary circulation.

Current opinion in anaesthesiology

N Rolf

Affiliations

  1. Klinik und Poliklinik für Anaesthesiologie und operative Intensivmedizin, Westfälische Wilhelms-Universität Münster, Albert Schweitzer-Strasse 33, D-48149 Münster, Germany.

PMID: 17013267 DOI: 10.1097/00001503-199810000-00012

Abstract

The coronary circulation is subject to modulation by the autonomic nervous system. Thus, sympathetic stimulation causes coronary vasodilation in healthy humans, whereas stenotic coronary arteries react by vasoconstriction in response to sympathetic stimulation. It is for this reason that experimental studies and clinical evidence revealed beneficial effects of a blockade of cardiac sympathetic drive by thoracic epidural anaesthesia on coronary perfusion and myocardial function in normal and in ischaemic myocardium. In contrast, segmental lumbar epidural anaesthesia leads to a compensatory increase in cardiac sympathetic outflow which may jeopardize myocardial areas dependent on perfusion by stenotic coronary arteries.

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