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Matsutani S. Links between repeated sequences. J Biomed Biotechnol. 2006;2006(1):13569doi: 10.1155/JBB/2006/13569.
Matsutani, S. (2006). Links between repeated sequences. Journal of biomedicine & biotechnology, 2006(1), 13569. https://doi.org/10.1155/JBB/2006/13569
Matsutani, Sachiko. "Links between repeated sequences." Journal of biomedicine & biotechnology vol. 2006,1 (2006): 13569. doi: https://doi.org/10.1155/JBB/2006/13569
Matsutani S. Links between repeated sequences. J Biomed Biotechnol. 2006;2006(1):13569. doi: 10.1155/JBB/2006/13569. PMID: 16877810; PMCID: PMC1510936.
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J Biomed Biotechnol. 2006;2006(1):13569. doi: 10.1155/JBB/2006/13569.

Links between repeated sequences.

Journal of biomedicine & biotechnology

Sachiko Matsutani

Affiliations

  1. Division of Microbiology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan.

PMID: 16877810 PMCID: PMC1510936 DOI: 10.1155/JBB/2006/13569

Abstract

L1 and Alu elements are long and short interspersed retrotransposable elements (LINEs and SINEs) in humans, respectively. Proteins encoded in the autonomous L1 mediate retrotransposition of the nonautonomous Alu and cellular mRNAs. Alu is the only active SINE in the human genome and is derived from 7SL RNA of signal recognition particle. In the other eukaryotic genomes, various tRNA- and 5S rRNA-derived SINEs are found. Some of the tRNA- and 5S rRNA-derived SINEs have partner LINEs of which 3' sequences are similar to those of the SINEs. One of the tRNA-derived SINEs is shown to be mobilized by its partner LINE. Many copies of tRNA and 5S rRNA pseudogenes are present in the human genome. These pseudogenes may have been generated via the retrotransposition process using L1 proteins. Although there are no sequence similarities between L1 and Alu, L1 functionally links with Alu and even cellular genes, impacting on our genome shaping.

References

  1. Mol Cell Biol. 2001 Feb;21(4):1429-39 - PubMed
  2. EMBO J. 2002 Nov 1;21(21):5899-910 - PubMed
  3. Genome Res. 2002 Jul;12(7):1060-7 - PubMed
  4. Cell. 1996 Nov 29;87(5):905-16 - PubMed
  5. Nat Genet. 2003 Sep;35(1):41-8 - PubMed
  6. Nat Genet. 2000 Apr;24(4):363-7 - PubMed
  7. Mol Cell Biol. 1990 Dec;10(12):6718-29 - PubMed
  8. Cell. 2002 Nov 1;111(3):433-44 - PubMed
  9. Cytogenet Genome Res. 2005;110(1-4):475-90 - PubMed
  10. Mol Genet Genomics. 2004 Feb;271(1):98-102 - PubMed
  11. Mol Biol Evol. 2003 May;20(5):694-702 - PubMed
  12. J Mol Biol. 2005 May 6;348(3):549-61 - PubMed
  13. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1872-7 - PubMed
  14. Cell. 1980 Nov;22(1 Pt 1):209-18 - PubMed
  15. Nat Genet. 1999 Jun;22(2):130 - PubMed
  16. Science. 1991 Dec 20;254(5039):1808-10 - PubMed
  17. Nucleic Acids Res. 1981 Dec 11;9(23):6439-56 - PubMed
  18. Cell. 1996 Nov 29;87(5):917-27 - PubMed
  19. Cell. 2002 Aug 9;110(3):277-80 - PubMed
  20. Nucleic Acids Res. 2004;32(13):3846-55 - PubMed
  21. Nature. 2004 May 20;429(6989):268-74 - PubMed
  22. Mol Cell Biol. 2005 Sep;25(17):7780-95 - PubMed
  23. EMBO J. 1996 Feb 1;15(3):630-9 - PubMed
  24. Trends Biochem Sci. 1996 Aug;21(8):283-5 - PubMed
  25. Nucleic Acids Res. 2003 Aug 1;31(15):4385-90 - PubMed
  26. Nat Rev Genet. 2002 May;3(5):370-9 - PubMed
  27. Nature. 2001 Feb 15;409(6822):860-921 - PubMed

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