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Barnes SE, Cygan ZT, Yates JK, et al. Raman spectroscopic monitoring of droplet polymerization in a microfluidic device. Analyst. 2006;131(9):1027-33doi: 10.1039/b603693g.
Barnes, S. E., Cygan, Z. T., Yates, J. K., Beers, K. L., & Amis, E. J. (2006). Raman spectroscopic monitoring of droplet polymerization in a microfluidic device. The Analyst, 131(9), 1027-33. https://doi.org/10.1039/b603693g
Barnes, Susan E, et al. "Raman spectroscopic monitoring of droplet polymerization in a microfluidic device." The Analyst vol. 131,9 (2006): 1027-33. doi: https://doi.org/10.1039/b603693g
Barnes SE, Cygan ZT, Yates JK, Beers KL, Amis EJ. Raman spectroscopic monitoring of droplet polymerization in a microfluidic device. Analyst. 2006 Sep;131(9):1027-33. doi: 10.1039/b603693g. Epub 2006 Jul 12. PMID: 17047803.
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Analyst. 2006 Sep;131(9):1027-33. doi: 10.1039/b603693g. Epub 2006 Jul 12.

Raman spectroscopic monitoring of droplet polymerization in a microfluidic device.

The Analyst

Susan E Barnes, Zuzanna T Cygan, Jesse K Yates, Kathryn L Beers, Eric J Amis

Affiliations

  1. NIST Combinatorial Methods Center, Polymers Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20879-8542, USA.

PMID: 17047803 DOI: 10.1039/b603693g

Abstract

Microfluidic methodologies are becoming increasingly important for rapid formulation and screening of materials, and development of analytical tools for multiple sample screening is a critical step in achieving a combinatorial 'lab on a chip' approach. This work demonstrates the application of Raman spectroscopy for analysis of monomer composition and degree of conversion of methacrylate-based droplets in a microfluidic device. Droplet formation was conducted by flow focusing on the devices, and a gradient of component composition was created by varying the flow rates of the droplet-phase fluids into the microchannels. Raman data were collected using a fiber optic probe from a stationary array of the droplets/particles on the device, followed by partial least squares (PLS) calibration of the first derivative (1600 cm(-1) to 1550 cm(-1)) allowing successful measurement of monomer composition with a standard error of calibration (SEC) of +/-1.95% by volume. Following photopolymerization, the percentage of double bond conversion of the individual particles was calculated from the depletion of the normalized intensity of the C[double bond, length as m-dash]C stretching vibration at 1605 cm(-1). Raman data allowed accurate measurement of the decrease in double bond conversion as a function of increasing crosslinker concentration. The results from the research demonstrate that Raman spectroscopy is an effective, on-chip analytical tool for screening polymeric materials on the micrometre scale.

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