Display options
Cite
Camara O, Kavallaris A, Nöschel H, et al. Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells. World J Surg Oncol. 2006;4:67doi: 10.1186/1477-7819-4-67.
Camara, O., Kavallaris, A., Nöschel, H., Rengsberger, M., Jörke, C., & Pachmann, K. (2006). Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells. World journal of surgical oncology, 467. https://doi.org/10.1186/1477-7819-4-67
Camara, Oumar, et al. "Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells." World journal of surgical oncology vol. 4 (2006): 67. doi: https://doi.org/10.1186/1477-7819-4-67
Camara O, Kavallaris A, Nöschel H, Rengsberger M, Jörke C, Pachmann K. Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells. World J Surg Oncol. 2006 Sep 26;4:67. doi: 10.1186/1477-7819-4-67. PMID: 17002789; PMCID: PMC1599731.
Copy Download .nbib Format: NLM
Share it on

World J Surg Oncol. 2006 Sep 26;4:67. doi: 10.1186/1477-7819-4-67.

Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells.

World journal of surgical oncology

Oumar Camara, Andreas Kavallaris, Helmut Nöschel, Matthias Rengsberger, Cornelia Jörke, Katharina Pachmann

Affiliations

  1. Frauenklinik der Friedrich Schiller Universtiät Jena, Bachstrasse 18, D-07740 Jena, Germany. [email protected]

PMID: 17002789 PMCID: PMC1599731 DOI: 10.1186/1477-7819-4-67

Abstract

BACKGROUND: Surgery of malignant tumors has long been suspected to be the reason for enhancement of growth of metastases with fatal outcome. This often prevented surgeons from touching the tumor if not absolutely necessary. We have shown in lung cancer patients that surgery, itself, leads to mobilization of tumor cells into peripheral blood. Some of the mobilized cells finding an appropriate niche might grow to form early metastases. Monitoring of tumor cell release during and the fate of such cells after surgery for breast cancer may help to reveal how metastases develop after surgery.

METHOD: We used the MAINTRAC analysis, a new tool for online observation of circulating epithelial cells, to monitor the number of epithelial cells before, 30 min, 60 min, three and seven days after surgery and during subsequent variable follow up in breast cancer patients.

RESULTS: Circulating epithelial cells were already present before surgery in all patients. During the first 30-60 min after surgery values did not change immediately. They started increasing during the following 3 to 4 days up to thousand fold in 85% of treated patients in spite of complete resection of the tumor with tumor free margins in all patients. There was a subsequent re-decrease, with cell numbers remaining above pre-surgery values in 58% of cases until onset of chemotherapy. In a few cases, where no further therapy or only hormone treatment was given due to low risk stage, cell numbers were monitored for up to three years. They remained elevated with no or a slow decrease over time. This was in contrast to the observation in a patient where surgery was performed for benign condition. She was monitored before surgery with no cells detectable. Epithelial cells increased up to more than 50,000 after surgery but followed by a complete reduction to below the threshold of detection.

CONCLUSION: Frequently before but regularly during surgery of breast cancer, epithelial cells are mobilized into circulation. Part of these cells, most probably normal or apoptotic cells, are cleared from the circulation as also shown to occur in benign conditions. After resection even if complete and of small tumors, cells can remain in the circulation over long times. Such cells may remain "dormant" but might settle and grow into metastases, if they find appropriate conditions, even after years.

References

  1. N Engl J Med. 2004 Aug 19;351(8):824-6 - PubMed
  2. Clin Chem Lab Med. 2001 Sep;39(9):811-7 - PubMed
  3. Am J Surg Pathol. 2004 Dec;28(12):1641-5 - PubMed
  4. Breast Cancer Res. 2000;2(6):400-7 - PubMed
  5. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7737-42 - PubMed
  6. Breast Cancer Res Treat. 2003 Dec;82(3):199-206 - PubMed
  7. Cancer. 2005 Mar 1;103(5):884-91 - PubMed
  8. Endocr Relat Cancer. 2001 Dec;8(4):265-86 - PubMed
  9. Eur J Cancer. 2003 Aug;39(12):1794-806 - PubMed
  10. Cancer Res. 2004 Oct 15;64(20):7336-45 - PubMed
  11. Cancer Cell. 2005 Sep;8(3):227-39 - PubMed
  12. Breast J. 2005 Mar-Apr;11 Suppl 1:S7-10 - PubMed
  13. Clin Chem Lab Med. 2005;43(6):617-27 - PubMed
  14. BMJ. 2005 Jan 29;330(7485):217 - PubMed
  15. World J Surg Oncol. 2005 Mar 31;3(1):18 - PubMed
  16. Ann Oncol. 2005 Sep;16(9):1449-57 - PubMed
  17. Clin Cancer Res. 2005 Aug 1;11(15):5657; author reply 5657-8 - PubMed
  18. Cancer Res. 2005 Jun 1;65(11):4698-706 - PubMed
  19. Cancer. 2005 Jan 15;103(2):358-67 - PubMed
  20. Cancer Invest. 1994;12(6):559-67 - PubMed
  21. J Natl Cancer Inst. 2006 Mar 1;98(5):316-25 - PubMed
  22. Breast Cancer Res. 2005;7(6):R975-9 - PubMed
  23. Clin Cancer Res. 2004 Dec 15;10(24):8152-62 - PubMed

Publication Types