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Khutorsky VE. Thermodynamic analysis of amines-lasalocid complex formation. Biophys Chem. 1997;69(2):161-6doi: 10.1016/s0301-4622(97)00086-0.
Khutorsky, V. E. (1997). Thermodynamic analysis of amines-lasalocid complex formation. Biophysical chemistry, 69(2), 161-6. https://doi.org/10.1016/s0301-4622(97)00086-0
Khutorsky, V E. "Thermodynamic analysis of amines-lasalocid complex formation." Biophysical chemistry vol. 69,2 (1997): 161-6. doi: https://doi.org/10.1016/s0301-4622(97)00086-0
Khutorsky VE. Thermodynamic analysis of amines-lasalocid complex formation. Biophys Chem. 1997 Dec 01;69(2):161-6. doi: 10.1016/s0301-4622(97)00086-0. PMID: 17029926.
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Biophys Chem. 1997 Dec 01;69(2):161-6. doi: 10.1016/s0301-4622(97)00086-0.

Thermodynamic analysis of amines-lasalocid complex formation.

Biophysical chemistry

V E Khutorsky

Affiliations

  1. Chemistry Department, Ben Gurion University of the Negev, Beer-Sheva, Israel.

PMID: 17029926 DOI: 10.1016/s0301-4622(97)00086-0

Abstract

The ionophore lasalocid A selectively transports amines across lipid membranes. Free energy differences of amine-lasalocid complex formation reactions and the activation barriers of the complex transport were calculated by the finite difference thermodynamic integration method. Four catecholamines were treated: serotonin > dopamine > noradrenaline > adrenaline. The concept of transfer selectivity was introduced, combining binding and activation barrier selectivities. The transfer selectivities correlate well with the relative selectivities of the amines under study.

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