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Biberfeld P, Ensoli B, Stürzl M, et al. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and HIV in pathogenesis of Kaposi's sarcoma. Curr Opin Infect Dis. 1998;11(2):97-105doi: 10.1097/00001432-199804000-00002.
Biberfeld, P., Ensoli, B., Stürzl, M., & Schulz, T. F. (1998). Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and HIV in pathogenesis of Kaposi's sarcoma. Current opinion in infectious diseases, 11(2), 97-105. https://doi.org/10.1097/00001432-199804000-00002
Biberfeld, P, et al. "Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and HIV in pathogenesis of Kaposi's sarcoma." Current opinion in infectious diseases vol. 11,2 (1998): 97-105. doi: https://doi.org/10.1097/00001432-199804000-00002
Biberfeld P, Ensoli B, Stürzl M, Schulz TF. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and HIV in pathogenesis of Kaposi's sarcoma. Curr Opin Infect Dis. 1998 Apr;11(2):97-105. doi: 10.1097/00001432-199804000-00002. PMID: 17033372.
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Curr Opin Infect Dis. 1998 Apr;11(2):97-105. doi: 10.1097/00001432-199804000-00002.

Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and HIV in pathogenesis of Kaposi's sarcoma.

Current opinion in infectious diseases

P Biberfeld, B Ensoli, M Stürzl, T F Schulz

Affiliations

  1. Immunopathology Laboratory, Institution for Oncology-Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

PMID: 17033372 DOI: 10.1097/00001432-199804000-00002

Abstract

Epidemiological studies have strengthened the case for Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 being the long-sought Kaposi sarcoma agent, but have also pointed to a role for other co-factors. Like other tumour viruses, Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 establishes a latent (persistent) infection in Kaposi sarcoma-spindle (tumorous) cells, but can also undergo lytic replication in these and other cell types. Several latent and lytic viral genes may play a role in the pathogenesis of Kaposi's sarcoma. Although Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 contains at least two genes with transforming properties, it has not yet been shown to be oncogenic in animals. This, and other studies on inflammatory/angiogenic cellular and viral cytokines as well as HIV-Tat, emphasizes the multifactorial complexity of the pathogenesis of Kaposi's sarcoma.

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