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Fejer SN, Csizmadia IG, Viskolcz B. Thermodynamic functions of conformational changes: conformational network of glycine diamide folding, entropy lowering, and informational accumulation. J Phys Chem A. 2006;110(49):13325-31doi: 10.1021/jp065595k.
Fejer, S. N., Csizmadia, I. G., & Viskolcz, B. (2006). Thermodynamic functions of conformational changes: conformational network of glycine diamide folding, entropy lowering, and informational accumulation. The journal of physical chemistry. A, 110(49), 13325-31. https://doi.org/10.1021/jp065595k
Fejer, Szilard N, et al. "Thermodynamic functions of conformational changes: conformational network of glycine diamide folding, entropy lowering, and informational accumulation." The journal of physical chemistry. A vol. 110,49 (2006): 13325-31. doi: https://doi.org/10.1021/jp065595k
Fejer SN, Csizmadia IG, Viskolcz B. Thermodynamic functions of conformational changes: conformational network of glycine diamide folding, entropy lowering, and informational accumulation. J Phys Chem A. 2006 Dec 14;110(49):13325-31. doi: 10.1021/jp065595k. PMID: 17149853.
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J Phys Chem A. 2006 Dec 14;110(49):13325-31. doi: 10.1021/jp065595k.

Thermodynamic functions of conformational changes: conformational network of glycine diamide folding, entropy lowering, and informational accumulation.

The journal of physical chemistry. A

Szilard N Fejer, Imre G Csizmadia, Bela Viskolcz

Affiliations

  1. Department of Chemistry and Chemical Informatics, Faculty of Education, University of Szeged, Szeged, Hungary 6701.

PMID: 17149853 DOI: 10.1021/jp065595k

Abstract

A refined grid of a conformational potential energy surface (PES) and a conformational entropy surface for glycine diamide was generated by ab initio molecular computations. The possible network of reaction paths was recognized in terms of the linear combinations of internal coordinates corresponding to conrotatory and disrotatory modes of motions. Such a Woodward-Hoffmann-like path selection principle was detected for the folding of this peptide from extended to some virtually cyclic structure. It seemed reasonable to assume that this principle (or its generalized form) might be applicable to protein folding. A reaction path network was projected on the potential energy, and a continuous entropy surface was constructed under the condition of reduced dimensionality. The low entropy of the folded conformation indicated an information accumulation between 326% and 1414% with respect to the fully extended or unfolded structure. It is found that the location of existing and 'latent' critical points on the surface is revealed by the extrema and inflection points of the entropy curve.

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