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Brunet LR, Dunne DW, Pearce EJ. Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection. Parasitol Today. 1998;14(10):422-7doi: 10.1016/s0169-4758(98)01317-9.
Brunet, L. R., Dunne, D. W., & Pearce, E. J. (1998). Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection. Parasitology today (Personal ed.), 14(10), 422-7. https://doi.org/10.1016/s0169-4758(98)01317-9
Brunet, L R, et al. "Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection." Parasitology today (Personal ed.) vol. 14,10 (1998): 422-7. doi: https://doi.org/10.1016/s0169-4758(98)01317-9
Brunet LR, Dunne DW, Pearce EJ. Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection. Parasitol Today. 1998 Oct;14(10):422-7. doi: 10.1016/s0169-4758(98)01317-9. PMID: 17040834.
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Parasitol Today. 1998 Oct;14(10):422-7. doi: 10.1016/s0169-4758(98)01317-9.

Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection.

Parasitology today (Personal ed.)

L R Brunet, D W Dunne, E J Pearce

Affiliations

  1. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

PMID: 17040834 DOI: 10.1016/s0169-4758(98)01317-9

Abstract

Of the estimated 200 million people infected with Schistosoma, a subset develop severe life-threatening disease. Adult Schistosoma mansoni are refractory to the immune response and are long-lived, causing chronic exposure to parasite antigen. Although the adult worms themselves are not antigenically inert, it is the parasite eggs that, by accumulating in the liver and traversing the intestinal wall, place a complex series of often-conflicting demands on the host's immune system. In this article, Laura Rosa Brunet, David Dunne and Edward Pearce discuss data from experimental studies in the mouse and field studies in endemic areas that combine to suggest that it is a failure to juggle this immunological conflict that results in severe disease.

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