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Asherson RA, Espinosa G, Cervera R, et al. Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment. J Clin Rheumatol. 2002;8(3):157-65
Asherson, R. A., Espinosa, G., Cervera, R., Font, J., & Reverter, J. C. (2002). Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 8(3), 157-65.
Asherson, Ronald A, et al. "Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment." Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases vol. 8,3 (2002): 157-65.
Asherson RA, Espinosa G, Cervera R, Font J, Reverter JC. Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment. J Clin Rheumatol. 2002 Jun;8(3):157-65. PMID: 17041346.
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J Clin Rheumatol. 2002 Jun;8(3):157-65.

Catastrophic antiphospholipid syndrome: proposed guidelines for diagnosis and treatment.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Ronald A Asherson, Gerard Espinosa, Ricard Cervera, Josep Font, Joan Carles Reverter

Affiliations

  1. Rheumatic Diseases Unit, Department of Medicine, University of Cape Town School of Medicine and Groote Schuur Hospital, Cape Town, South Africa.

PMID: 17041346

Abstract

The term "catastrophic" antiphospholipid syndrome (APS) was introduced to define an accelerated form of APS resulting in multi-organ failure. Although patients with the catastrophic form represent less than 1% of all patients with APS, they are usually in a life-threatening medical situation that requires high clinical awareness. In this article, we propose guidelines for the diagnosis and treatment of patients with catastrophic APS, based on the cumulated published experience of 130 cases with this syndrome. We believe that it is essential that this syndrome should be diagnosed early and treated aggressively. The combination of high doses of heparin and corticosteroids plus intravenous gamma globulins or plasmapheresis is proposed as the treatment of choice in patients with this severe condition. In addition, preventive measures in patients with APS may be effective to avoid the development of catastrophic APS. We recommend that these proposed guidelines be tested in future prospective, collaborative studies to assess clearly the real prevalence and the best therapy for this life-threatening condition.

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