Display options
Cite
Cowey S, Hardy RW. The metabolic syndrome: A high-risk state for cancer?. Am J Pathol. 2006;169(5):1505-22doi: 10.2353/ajpath.2006.051090.
Cowey, S., & Hardy, R. W. (2006). The metabolic syndrome: A high-risk state for cancer?. The American journal of pathology, 169(5), 1505-22. https://doi.org/10.2353/ajpath.2006.051090
Cowey, Stephanie, and Hardy, Robert W. "The metabolic syndrome: A high-risk state for cancer?." The American journal of pathology vol. 169,5 (2006): 1505-22. doi: https://doi.org/10.2353/ajpath.2006.051090
Cowey S, Hardy RW. The metabolic syndrome: A high-risk state for cancer?. Am J Pathol. 2006 Nov;169(5):1505-22. doi: 10.2353/ajpath.2006.051090. PMID: 17071576; PMCID: PMC1780220.
Copy Download .nbib Format: NLM
Share it on

Am J Pathol. 2006 Nov;169(5):1505-22. doi: 10.2353/ajpath.2006.051090.

The metabolic syndrome: A high-risk state for cancer?.

The American journal of pathology

Stephanie Cowey, Robert W Hardy

Affiliations

  1. Department of Pathology, University of Alabama at Birmingham, 701 South 19th St., LHRB Room 531, Birmingham, AL 35294-0007, USA.

PMID: 17071576 PMCID: PMC1780220 DOI: 10.2353/ajpath.2006.051090

Abstract

The metabolic syndrome is composed of cardiovascular risk factors including increased body mass index/waist circumference, blood pressure, plasma glucose, and triglycerides, as well as decreased high-density lipoprotein cholesterol. The essence of the metabolic syndrome lies in the clustering of these risk factors, which are associated with cardiovascular disease. Interestingly, most of the components of the metabolic syndrome have individually been linked in some way to the development of cancer. However, epidemiological studies linking the metabolic syndrome to cancer are scarce. Nevertheless, two such studies indicate that the clustering of metabolic syndrome components significantly increases the risk of colon cancer mortality compared with the individual components. The purpose of this review is to further explore the potential relationship between the metabolic syndrome and cancer risk. Specifically, we examine the hypothesis that individual components of the metabolic syndrome contribute to the development of several processes, including insulin resistance, aromatase activity, adipokine production, angiogenesis, glucose utilization, and oxidative stress/DNA damage, which can work together to increase cancer risk beyond that of the individual components alone. We propose that the metabolic syndrome be considered as a high-risk state for certain types of cancer and that this relationship should be systematically explored across cancer types.

References

  1. Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):863-73 - PubMed
  2. J Surg Res. 2004 Feb;116(2):337-49 - PubMed
  3. Science. 1956 Feb 24;123(3191):309-14 - PubMed
  4. N Engl J Med. 2003 Apr 24;348(17):1625-38 - PubMed
  5. Dig Dis Sci. 2005 Mar;50(3):499-505 - PubMed
  6. Cancer Causes Control. 2004 Sep;15(7):707-19 - PubMed
  7. Diabetes Care. 2005 Sep;28(9):2289-304 - PubMed
  8. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):466-72 - PubMed
  9. Prostate Cancer Prostatic Dis. 2005;8(4):316-20 - PubMed
  10. J Clin Oncol. 2002 Jan 1;20(1):42-51 - PubMed
  11. Endocr Rev. 2005 May;26(3):439-51 - PubMed
  12. Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):385-91 - PubMed
  13. Int J Obes (Lond). 2006 Jan;30(1):156-63 - PubMed
  14. Mol Cell Biochem. 2004 Nov;266(1-2):37-56 - PubMed
  15. Eur J Obstet Gynecol Reprod Biol. 2002 Nov 15;105(2):161-5 - PubMed
  16. Br J Cancer. 2001 Feb 2;84(3):417-22 - PubMed
  17. Am J Epidemiol. 2005 May 15;161(10):939-47 - PubMed
  18. Br J Cancer. 1994 Nov;70(5):950-3 - PubMed
  19. Circulation. 2004 Jan 27;109(3):433-8 - PubMed
  20. J Natl Cancer Inst. 2003 Aug 20;95(16):1218-26 - PubMed
  21. Carcinogenesis. 2002 Nov;23(11):1781-9 - PubMed
  22. Eur J Cancer Prev. 2001 Feb;10(1):15-32 - PubMed
  23. Endocr Rev. 2005 May;26(3):331-45 - PubMed
  24. Int J Cancer. 1998 May 29;76(5):647-51 - PubMed
  25. Annu Rev Med. 2005;56:45-62 - PubMed
  26. Oncogene. 2004 Aug 23;23(38):6365-78 - PubMed
  27. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S - PubMed
  28. Int J Obes (Lond). 2005 Nov;29(11):1308-14 - PubMed
  29. Cancer Causes Control. 1994 Nov;5(6):501-9 - PubMed
  30. Int J Cancer. 2003 May 10;104(6):669-76 - PubMed
  31. J Cell Physiol. 2005 Mar;202(3):654-62 - PubMed
  32. Eur J Obstet Gynecol Reprod Biol. 2005 Feb 1;118(2):239-40 - PubMed
  33. Eur J Cancer. 2006 Jan;42(1):84-90 - PubMed
  34. J Clin Oncol. 2005 Apr 20;23(12):2840-55 - PubMed
  35. JAMA. 2005 Jan 12;293(2):194-202 - PubMed
  36. Nat Rev Cancer. 2004 Aug;4(8):579-91 - PubMed
  37. Ann N Y Acad Sci. 2001 Apr;928:287-95 - PubMed
  38. J Clin Invest. 2006 Jul;116(7):1793-801 - PubMed
  39. Clin Endocrinol (Oxf). 2001 May;54(5):563-71 - PubMed
  40. Cancer Res. 1992 Jul 15;52(14):3924-30 - PubMed
  41. Clin Biochem. 2001 Feb;34(1):71-6 - PubMed
  42. Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):937-41 - PubMed
  43. J Natl Cancer Inst. 1999 Jul 7;91(13):1147-54 - PubMed
  44. Am J Physiol Renal Physiol. 2001 Mar;280(3):F480-6 - PubMed
  45. Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2936-42 - PubMed
  46. Obes Res. 2004 Feb;12(2):180-6 - PubMed
  47. J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56 - PubMed
  48. Pharmacol Rev. 2004 Dec;56(4):549-80 - PubMed
  49. Atherosclerosis. 2000 Jan;148(1):17-21 - PubMed
  50. Annu Rev Public Health. 2005;26:115-40 - PubMed
  51. J Cancer Res Clin Oncol. 2004 Nov;130(11):687-93 - PubMed
  52. J Allergy Clin Immunol. 2005 May;115(5):911-9; quiz 920 - PubMed
  53. Breast Dis. 2003;17:41-7 - PubMed
  54. Clin Exp Hypertens. 2004 Aug;26(6):547-56 - PubMed
  55. Mol Cell Biochem. 2005 Jan;268(1-2):19-24 - PubMed
  56. Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43 - PubMed
  57. Blood Press. 2004;13(1):47-55 - PubMed
  58. J Clin Invest. 2004 Dec;114(12):1752-61 - PubMed
  59. J Clin Endocrinol Metab. 2004 Feb;89(2):447-52 - PubMed
  60. Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S530-50; discussion S609-10 - PubMed
  61. Diabetologia. 2003 Nov;46(11):1483-8 - PubMed
  62. Int J Cancer. 2004 Sep 20;111(5):762-71 - PubMed
  63. Cancer Res. 2000 Jan 15;60(2):245-8 - PubMed
  64. Cancer Causes Control. 2002 Oct;13(8):741-51 - PubMed
  65. Cancer Res. 2005 Mar 15;65(6):2085-8 - PubMed
  66. Br J Nutr. 2004 Sep;92(3):347-55 - PubMed
  67. Int J Cancer. 2006 Jul 1;119(1):236-8 - PubMed
  68. Diabetes. 1988 Dec;37(12):1595-607 - PubMed
  69. Am J Epidemiol. 1998 Apr 1;147(7):670-80 - PubMed
  70. Int J Epidemiol. 2006 Feb;35(1):159-66 - PubMed
  71. Asian Pac J Cancer Prev. 2005 Oct-Dec;6(4):485-9 - PubMed
  72. J Natl Cancer Inst. 2004 Aug 4;96(15):1152-60 - PubMed
  73. Annu Rev Med. 2003;54:131-52 - PubMed
  74. Growth Horm IGF Res. 2004 Aug;14(4):261-9 - PubMed
  75. J Appl Physiol (1985). 2002 Aug;93(2):788-96 - PubMed
  76. Hypertension. 2006 Jan;47(1):45-50 - PubMed
  77. J Anim Sci. 2004 Mar;82(3):925-34 - PubMed
  78. Am J Med. 2002 Apr 15;112(6):479-86 - PubMed
  79. Oncology. 2002;63(4):317-32 - PubMed

MeSH terms

Publication Types

Grant support