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Op den Buijs J, Juloski ALj, Ivanics T, et al. Identification of a switching model of calcium cycling in isolated rat hearts. Conf Proc IEEE Eng Med Biol Soc. 2004;2004:841-4doi: 10.1109/IEMBS.2004.1403289.
Op den Buijs, J., Juloski, A. L. j., Ivanics, T., Ligeti, L., van der Vusse, G. J., & van Riel, N. A. (2004). Identification of a switching model of calcium cycling in isolated rat hearts. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2004841-4. https://doi.org/10.1109/IEMBS.2004.1403289
Op den Buijs, J, et al. "Identification of a switching model of calcium cycling in isolated rat hearts." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference vol. 2004 (2004): 841-4. doi: https://doi.org/10.1109/IEMBS.2004.1403289
Op den Buijs J, Juloski ALj, Ivanics T, Ligeti L, van der Vusse GJ, van Riel NA. Identification of a switching model of calcium cycling in isolated rat hearts. Conf Proc IEEE Eng Med Biol Soc. 2004;2004:841-4. doi: 10.1109/IEMBS.2004.1403289. PMID: 17271808.
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Conf Proc IEEE Eng Med Biol Soc. 2004;2004:841-4. doi: 10.1109/IEMBS.2004.1403289.

Identification of a switching model of calcium cycling in isolated rat hearts.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

J Op den Buijs, A Lj Juloski, T Ivanics, L Ligeti, G J van der Vusse, N A W van Riel

Affiliations

  1. Dept. of Electr. Eng., Eindhoven Univ. of Technol., Netherlands.

PMID: 17271808 DOI: 10.1109/IEMBS.2004.1403289

Abstract

So far, the processes involved in regulation of intracellular calcium (Ca/sub i//sup 2+/) in cardiomyocytes have been mainly studied through biochemical and isolated cell analysis. Here, we present a novel technique to model and identify cardiac Ca/sub i//sup 2+/-cycling under physiologically relevant conditions in the intact beating heart. Ca/sub i//sup 2+/ was measured using fluorescence techniques in ex vivo perfused rat hearts. For analysis, we developed a parametric mathematical model, switching between active and inactive calcium release. The kinetic parameters of the two submodes of the model were computed using a recently developed technique from hybrid system identification. Application of the method to control and isoproterenol-stimulated hearts resulted in parameter values within a physiologically reliable range.

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