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Conf Proc IEEE Eng Med Biol Soc. 2004;2004:2052-4. doi: 10.1109/IEMBS.2004.1403603.

In vivo noninvasive monitoring of cerebral blood with optoacoustic technique.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Y Petrov, D Prough, D Deyo, I Petrova, M Motamedi, R Esenaliev

Affiliations

  1. Center for Biomedical Engineering, University of Texas, Galveston, TX 77555, USA.

PMID: 17272123 DOI: 10.1109/IEMBS.2004.1403603

Abstract

We present the results of blood oxygenation (oxyhemoglobin saturation) measurements using an optoacoustic system in vivo in the superior sagittal sinus of sheep. The system included a nanosecond Nd:YAG laser as a source of radiation and a specially designed optoacoustic probe for signal detection. The optoacoustic signal induced in the superior sagittal sinus by the nanosecond laser pulses correlated well with actual oxyhemoglobin saturation measured with CO-oximeter. We propose to use a two- or multi- wavelength optoacoustic system for noninvasive continuous monitoring of cerebral venous blood oxygenation. The spectra of effective attenuation coefficient were measured in the range 680-1300 nm for oxy- and deoxygenated whole blood and can be employed for calibration of the system.

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