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Que EL, Chang CJ. A smart magnetic resonance contrast agent for selective copper sensing. J Am Chem Soc. 2006;128(50):15942-3doi: 10.1021/ja065264l.
Que, E. L., & Chang, C. J. (2006). A smart magnetic resonance contrast agent for selective copper sensing. Journal of the American Chemical Society, 128(50), 15942-3. https://doi.org/10.1021/ja065264l
Que, Emily L, and Chang, Christopher J. "A smart magnetic resonance contrast agent for selective copper sensing." Journal of the American Chemical Society vol. 128,50 (2006): 15942-3. doi: https://doi.org/10.1021/ja065264l
Que EL, Chang CJ. A smart magnetic resonance contrast agent for selective copper sensing. J Am Chem Soc. 2006 Dec 20;128(50):15942-3. doi: 10.1021/ja065264l. PMID: 17165700.
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J Am Chem Soc. 2006 Dec 20;128(50):15942-3. doi: 10.1021/ja065264l.

A smart magnetic resonance contrast agent for selective copper sensing.

Journal of the American Chemical Society

Emily L Que, Christopher J Chang

Affiliations

  1. Department of Chemistry, University of California, Berkeley, California 94720, USA.

PMID: 17165700 DOI: 10.1021/ja065264l

Abstract

We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ over abundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.

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