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Isohanni M, Miettunen J, Mäki P, et al. Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study. World Psychiatry. 2006;5(3):168-71
Isohanni, M., Miettunen, J., Mäki, P., Murray, G. K., Ridler, K., Lauronen, E., Moilanen, K., Alaräisänen, A., Haapea, M., Isohanni, I., Ivleva, E., Tamminga, C., McGrath, J., & Koponen, H. (2006). Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study. World psychiatry : official journal of the World Psychiatric Association (WPA), 5(3), 168-71.
Isohanni, Matti, et al. "Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study." World psychiatry : official journal of the World Psychiatric Association (WPA) vol. 5,3 (2006): 168-71.
Isohanni M, Miettunen J, Mäki P, Murray GK, Ridler K, Lauronen E, Moilanen K, Alaräisänen A, Haapea M, Isohanni I, Ivleva E, Tamminga C, McGrath J, Koponen H. Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study. World Psychiatry. 2006 Oct;5(3):168-71. PMID: 17139352; PMCID: PMC1636118.
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World Psychiatry. 2006 Oct;5(3):168-71.

Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Matti Isohanni, Jouko Miettunen, Pirjo Mäki, Graham K Murray, Khanum Ridler, Erika Lauronen, Kristiina Moilanen, Antti Alaräisänen, Marianne Haapea, Irene Isohanni, Elena Ivleva, Carol Tamminga, John McGrath, Hannu Koponen

Affiliations

  1. Department of Psychiatry, University of Oulu, Finland;

PMID: 17139352 PMCID: PMC1636118

Abstract

This paper updates single risk factors identified by the Northern Finland 1966 Birth Cohort Study up to the end of year 2001 or age 34. Impaired performance (e.g., delayed motor or intellectual development) or adverse exposures (e.g., pregnancy and birth complications, central nervous system diseases) are associated with an increased risk for schizophrenia. However, upper social class girls and clever schoolboys also have an increased risk to develop schizophrenia, contrasted to their peers. Individuals who subsequently develop schizophrenia follow a developmental trajectory that partly and subtly differs from that of the general population; this trajectory lacks flexibility and responsiveness compared to control subjects, at least in the early stages. We propose a descriptive, lifespan, multilevel systems model on the development and course of schizophrenia.

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