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Masciotti J, Abdoulaev G, Provenzano F, et al. Optical Tomographic and Magnetic Resonance Imaging of Tumor Growth and Regression in Mice treated with VEGF Blockade. Conf Proc IEEE Eng Med Biol Soc. 2005;2006:205-8doi: 10.1109/IEMBS.2005.1616379.
Masciotti, J., Abdoulaev, G., Provenzano, F., Hur, J., Papa, J., Bae, J., Huang, J., Yamashiro, D., Kandel, J., & Hielscher, A. (2005). Optical Tomographic and Magnetic Resonance Imaging of Tumor Growth and Regression in Mice treated with VEGF Blockade. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006205-8. https://doi.org/10.1109/IEMBS.2005.1616379
Masciotti, J, et al. "Optical Tomographic and Magnetic Resonance Imaging of Tumor Growth and Regression in Mice treated with VEGF Blockade." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference vol. 2006 (2005): 205-8. doi: https://doi.org/10.1109/IEMBS.2005.1616379
Masciotti J, Abdoulaev G, Provenzano F, Hur J, Papa J, Bae J, Huang J, Yamashiro D, Kandel J, Hielscher A. Optical Tomographic and Magnetic Resonance Imaging of Tumor Growth and Regression in Mice treated with VEGF Blockade. Conf Proc IEEE Eng Med Biol Soc. 2005;2006:205-8. doi: 10.1109/IEMBS.2005.1616379. PMID: 17282148.
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Conf Proc IEEE Eng Med Biol Soc. 2005;2006:205-8. doi: 10.1109/IEMBS.2005.1616379.

Optical Tomographic and Magnetic Resonance Imaging of Tumor Growth and Regression in Mice treated with VEGF Blockade.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

J Masciotti, G Abdoulaev, F Provenzano, J Hur, J Papa, J Bae, J Huang, D Yamashiro, J Kandel, A Hielscher

Affiliations

  1. Dept. Biomedical Engineering, Columbia University, 500 West 120th Street, New York, NY 10027 USA.

PMID: 17282148 DOI: 10.1109/IEMBS.2005.1616379

Abstract

Small animal imaging systems now allow researchers to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images which are sensitive to blood volume, blood flow, and metabolic rate of oxygen. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution and insensitive to blood flow, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. We illustrate how these imaging modalities can supplement each other and cross validation can be performed by applying both modalities to imaging of tumors growth & regression in mice that are treated with a vascular endothelial growth factor (VEGF) antagonist.

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