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Shidham VB, Pandit AW, Rao RN, et al. Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps. BMC Clin Pathol. 2007;7:2doi: 10.1186/1472-6890-7-2.
Shidham, V. B., Pandit, A. W., Rao, R. N., Basir, Z., & Shidham, A. (2007). Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps. BMC clinical pathology, 72. https://doi.org/10.1186/1472-6890-7-2
Shidham, Vinod B, et al. "Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps." BMC clinical pathology vol. 7 (2007): 2. doi: https://doi.org/10.1186/1472-6890-7-2
Shidham VB, Pandit AW, Rao RN, Basir Z, Shidham A. Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps. BMC Clin Pathol. 2007 Mar 07;7:2. doi: 10.1186/1472-6890-7-2. PMID: 17343753; PMCID: PMC1829396.
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BMC Clin Pathol. 2007 Mar 07;7:2. doi: 10.1186/1472-6890-7-2.

Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps.

BMC clinical pathology

Vinod B Shidham, Ashwini W Pandit, R Nagarjun Rao, Zainab Basir, Anjani Shidham

Affiliations

  1. Dept of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA. [email protected]

PMID: 17343753 PMCID: PMC1829396 DOI: 10.1186/1472-6890-7-2

Abstract

BACKGROUND: Fine needle aspiration biopsy (FNAB) cytology has been a highly effective methodology for tissue diagnosis and for various ancillary studies including molecular tests. In addition to other benefits, FNAB predominantly retrieves the diagnostic loosely cohesive cells in the lesion as compared to the adjacent supporting stroma with relatively higher cohesiveness. However, FNAB procedure performed with currently available resources is highly skill dependent with inter-performer variability, which compromises its full potential as a diagnostic tool. In this study we report a device overcoming these limitations.

METHODS: 'Tissue Harvester with Functional Valve' (THFV) was evaluated as part of a phase 1 National Institute of Health (NIH) research grant under Small Business Technology Transfer (STTR) Program. Working prototypes of the device were prepared. Each of the four cytopathologists with previous cytopathology fellowship training and experience in performing FNAB evaluated 5 THFV and 5 hypodermic needles resulting in 40 specimens (20 with THFV, 20 with hypodermic needles). A piece of fresh cattle liver stuffed in latex glove was used as the specimen. Based on these results a finished design was finalized.

RESULTS: The smears and cell blocks prepared from the specimens obtained by THFV were superior in terms of cellularity to specimens obtained with hypodermic needles. The tissuecrit of specimens obtained with THFV ranged from 70 to 100 microl (mean 87, SD 10), compared to 17 to 30 microl (mean 24, SD 4) with conventional hypodermic needles (p < .0001, Student t-test). The technical ease [on a scale of 1 (easy) to 5 (difficult)] with THFV ranged from 1 to 2 as compared to 2 to 3 with hypodermic needles.

CONCLUSION: The specimen yield with the new THFV was significantly higher when compared to hypodermic needles. Also, the FNAB procedure with THFV was relatively easier in comparison with hypodermic needles. The final version of Shidham's THFV device would improve the FNAB specimen yield by eliminating the skill factor. The increased specimen yield by this device would also facilitate wider application of FNAB specimens for various ancillary tests, including molecular tests.

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