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Gunjigake KK, Goto T, Nakao K, et al. Correlation between the appearance of neuropeptides in the rat trigeminal ganglion and reinnervation of the healing root socket after tooth extraction. Acta Histochem Cytochem. 2006;39(3):69-77doi: 10.1267/ahc.05057.
Gunjigake, K. K., Goto, T., Nakao, K., Konoo, T., Kobayashi, S., & Yamaguchi, K. (2006). Correlation between the appearance of neuropeptides in the rat trigeminal ganglion and reinnervation of the healing root socket after tooth extraction. Acta histochemica et cytochemica, 39(3), 69-77. https://doi.org/10.1267/ahc.05057
Gunjigake, Kaori K, et al. "Correlation between the appearance of neuropeptides in the rat trigeminal ganglion and reinnervation of the healing root socket after tooth extraction." Acta histochemica et cytochemica vol. 39,3 (2006): 69-77. doi: https://doi.org/10.1267/ahc.05057
Gunjigake KK, Goto T, Nakao K, Konoo T, Kobayashi S, Yamaguchi K. Correlation between the appearance of neuropeptides in the rat trigeminal ganglion and reinnervation of the healing root socket after tooth extraction. Acta Histochem Cytochem. 2006 Jul 01;39(3):69-77. doi: 10.1267/ahc.05057. Epub 2006 Apr 19. PMID: 17327926; PMCID: PMC1790972.
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Acta Histochem Cytochem. 2006 Jul 01;39(3):69-77. doi: 10.1267/ahc.05057. Epub 2006 Apr 19.

Correlation between the appearance of neuropeptides in the rat trigeminal ganglion and reinnervation of the healing root socket after tooth extraction.

Acta histochemica et cytochemica

Kaori K Gunjigake, Tetsuya Goto, Kayoko Nakao, Tetsuro Konoo, Shigeru Kobayashi, Kazunori Yamaguchi

Affiliations

  1. Division of Orofacial Functions and Orthodontics, Kyushu Dental College, Kitakyushu 803-8580, Japan.

PMID: 17327926 PMCID: PMC1790972 DOI: 10.1267/ahc.05057

Abstract

The neuropeptide substance P (SP) modulates bone metabolism. This study examined the temporal appearance of the neuropeptides SP and brain-derived nerve growth factor (BDNF) and their receptors (neurokinin-1 receptor (NK1-R) and Trk B, respectively) in the rat trigeminal ganglion to investigate the role of neuropeptides in healing after tooth extraction. Rats were anesthetized and their upper right first molars were extracted; the rats were sacrificed 3 hours and 1-21 days after extraction. Their trigeminal ganglion and maxilla were removed, and cryosections were prepared and immunostained using specific antibodies against SP, BDNF, NK1-R, and Trk B. In the tooth sockets after extraction, new bone and a few SP--immunoreactive nerve fibers were first seen at day 7, and bone completely filled the sockets at day 21. In the trigeminal ganglion, the proportions of NK1-R-, BDNF-, and Trk B-immuno-reactive neurons changed similarly, i.e., they initially decreased, increased rapidly to -maximum levels by day 3, and then decreased gradually to control levels until 21 days. These findings suggest that the appearance of neuropeptides in the trigeminal ganglion, the reinnervation of SP-immunoreactive nerve fibers, and bone repair in the tooth socket during healing after extraction were correlated.

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