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Roy G, Mugesh G. Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl. 2006;23214doi: 10.1155/BCA/2006/23214.
Roy, G., & Mugesh, G. (2006). Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorganic chemistry and applications, 23214. https://doi.org/10.1155/BCA/2006/23214
Roy, Gouriprasanna, and Mugesh, G. "Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions." Bioinorganic chemistry and applications vol. (2006): 23214. doi: https://doi.org/10.1155/BCA/2006/23214
Roy G, Mugesh G. Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl. 2006;23214. doi: 10.1155/BCA/2006/23214. Epub 2006 Nov 12. PMID: 17497002; PMCID: PMC1794076.
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Bioinorg Chem Appl. 2006;23214. doi: 10.1155/BCA/2006/23214. Epub 2006 Nov 12.

Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions.

Bioinorganic chemistry and applications

Gouriprasanna Roy, G Mugesh

Affiliations

  1. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India.

PMID: 17497002 PMCID: PMC1794076 DOI: 10.1155/BCA/2006/23214

Abstract

Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the selenenyl iodide intermediate (E-SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone synthesis and found that the replacement of sulfur with selenium in MMI leads to an interesting compound that may reversibly block the thyroid hormone synthesis. Our recent results on the inhibition of lactoperoxidase (LPO)-catalyzed oxidation and iodination reactions by antithyroid drugs are described.

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