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Kuznetsova AA, Chernonosov AA, Kuznetsov NA, et al. Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Bioinorg Chem Appl. 2006;23560doi: 10.1155/BCA/2006/23560.
Kuznetsova, A. A., Chernonosov, A. A., Kuznetsov, N. A., Koval, V. V., Knorre, D. G., & Fedorova, O. S. (2006). Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Bioinorganic chemistry and applications, 23560. https://doi.org/10.1155/BCA/2006/23560
Kuznetsova, Alexandra A, et al. "Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide." Bioinorganic chemistry and applications vol. (2006): 23560. doi: https://doi.org/10.1155/BCA/2006/23560
Kuznetsova AA, Chernonosov AA, Kuznetsov NA, Koval VV, Knorre DG, Fedorova OS. Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Bioinorg Chem Appl. 2006;23560. doi: 10.1155/BCA/2006/23560. Epub 2006 Dec 18. PMID: 17497004; PMCID: PMC1800914.
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Bioinorg Chem Appl. 2006;23560. doi: 10.1155/BCA/2006/23560. Epub 2006 Dec 18.

Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide.

Bioinorganic chemistry and applications

Alexandra A Kuznetsova, Alexander A Chernonosov, Nikita A Kuznetsov, Vladimir V Koval, Dmitri G Knorre, Olga S Fedorova

Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.

PMID: 17497004 PMCID: PMC1800914 DOI: 10.1155/BCA/2006/23560

Abstract

Design of chemically modified oligonucleotides for regulation of gene expression has attracted considerable attention over the last decades. One actively pursued approach involves antisense or antigene constructs carrying reactive groups, many of these based on transition metal complexes. The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide. In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H(2)O(2).

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