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Mathews KA, Doherty T, Dyson DH, et al. Nephrotoxicity in dogs associated with methoxyflurane anesthesia and flunixin meglumine analgesia. Can Vet J. 1990;31(11):766-71
Mathews, K. A., Doherty, T., Dyson, D. H., Wilcock, B., & Valliant, A. (1990). Nephrotoxicity in dogs associated with methoxyflurane anesthesia and flunixin meglumine analgesia. The Canadian veterinary journal = La revue veterinaire canadienne, 31(11), 766-71.
Mathews, K A, et al. "Nephrotoxicity in dogs associated with methoxyflurane anesthesia and flunixin meglumine analgesia." The Canadian veterinary journal = La revue veterinaire canadienne vol. 31,11 (1990): 766-71.
Mathews KA, Doherty T, Dyson DH, Wilcock B, Valliant A. Nephrotoxicity in dogs associated with methoxyflurane anesthesia and flunixin meglumine analgesia. Can Vet J. 1990 Nov;31(11):766-71. PMID: 17423691; PMCID: PMC1480876.
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Can Vet J. 1990 Nov;31(11):766-71.

Nephrotoxicity in dogs associated with methoxyflurane anesthesia and flunixin meglumine analgesia.

The Canadian veterinary journal = La revue veterinaire canadienne

K A Mathews, T Doherty, D H Dyson, B Wilcock, A Valliant

PMID: 17423691 PMCID: PMC1480876

Abstract

Uremia unexpectedly developed in five dogs 24 hours after undergoing thoracotomy in a student laboratory. In all dogs general anesthesia had been maintained with methoxyflurane, muscle relaxation had been induced with gallamine, and each dog received a single intravenous dose of 1.0 mg/kg flunixin meglumine for analgesia upon termination of anesthesia. In a subsequent group of dogs undergoing an orthopedic procedure, we assessed the effects on renal function of methoxyflurane anesthesia plus oxymorphone, or of methoxyflurane or halothane anesthesia in combination with a single IM 1.0 mg/kg dose of flunixin meglumine. Significant elevations in serum urea and creatinine values, and necrosis of collecting ducts and loops of Henle, were noted only in the dogs receiving methoxyflurane and flunixin meglumine.We conclude that the use of combination of methoxyflurane and flunixin meglumine is contraindicated in dogs.

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