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Rao VR, Ramanjeneyulu R, Rao DM, et al. Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum. Bioinformation. 2006;1(3):81-2doi: 10.6026/97320630001081.
Rao, V. R., Ramanjeneyulu, R., Rao, D. M., & Kumar, C. S. (2006). Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum. Bioinformation, 1(3), 81-2. https://doi.org/10.6026/97320630001081
Rao, Venkata Rao Dodaghatta Krishna, et al. "Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum." Bioinformation vol. 1,3 (2006): 81-2. doi: https://doi.org/10.6026/97320630001081
Rao VR, Ramanjeneyulu R, Rao DM, Kumar CS. Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum. Bioinformation. 2006 Jan 24;1(3):81-2. doi: 10.6026/97320630001081. PMID: 17597860; PMCID: PMC1891664.
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Bioinformation. 2006 Jan 24;1(3):81-2. doi: 10.6026/97320630001081.

Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum.

Bioinformation

Venkata Rao Dodaghatta Krishna Rao, Rallapalli Ramanjeneyulu, Dowlathabad Muralidhara Rao, Chitta Suresh Kumar

Affiliations

  1. Department of Microbiology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.

PMID: 17597860 PMCID: PMC1891664 DOI: 10.6026/97320630001081

Abstract

Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema pallidum. Comparative genome analysis shows the absence of its sequence homolog in eukaryotes. The structure of class I lysyl tRNA synthetase from Treponema pallidum is unknown and the difficulties in the in vitro culturing of Treponema makes it non-trivial. We used the structural template of class I lysyl tRNA synthetase from the archaea Pyrococcus horikoshii for modeling the Treponema pallidum lysyl tRNA synthetase structure. Thus, we propose the usefulness of the modeled class I lysyl tRNA synthetase for the design of suitable inhibitors towards the treatment of syphilis.

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