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Wong FS, Wen L. B cells in autoimmune diabetes. Rev Diabet Stud. 2005;2(3):121-35doi: 10.1900/RDS.2005.2.121.
Wong, F. S., & Wen, L. (2005). B cells in autoimmune diabetes. The review of diabetic studies : RDS, 2(3), 121-35. https://doi.org/10.1900/RDS.2005.2.121
Wong, F Susan, and Wen, Li. "B cells in autoimmune diabetes." The review of diabetic studies : RDS vol. 2,3 (2005): 121-35. doi: https://doi.org/10.1900/RDS.2005.2.121
Wong FS, Wen L. B cells in autoimmune diabetes. Rev Diabet Stud. 2005;2(3):121-35. doi: 10.1900/RDS.2005.2.121. Epub 2005 Nov 10. PMID: 17491687; PMCID: PMC1783559.
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Rev Diabet Stud. 2005;2(3):121-35. doi: 10.1900/RDS.2005.2.121. Epub 2005 Nov 10.

B cells in autoimmune diabetes.

The review of diabetic studies : RDS

F Susan Wong, Li Wen

Affiliations

  1. Department of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom. [email protected]

PMID: 17491687 PMCID: PMC1783559 DOI: 10.1900/RDS.2005.2.121

Abstract

Autoantibodies have been used as good markers for the prediction of future development of type 1 diabetes mellitus (T1DM), but are not thought to be pathogenic in this disease. The role of B cells that produce autoantibodies in the pathogenesis of human T1DM is largely unknown. In the non-obese diabetic (NOD) mouse model of autoimmune diabetes, it has been shown that B cells may contribute multifariously to the pathogenesis of the disease. Some aspects of deficiencies of B cell tolerance may lead to the circulation of autoreactive B cells. In addition, the antigen-presenting function of autoantigen specific B cells is likely to be particularly important, and autoantibodies are also considered to play a critical role. This review discusses the possible aspects of B cells involved in the development of autoimmune diabetes.

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