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Science. 1969 Dec 19;166(3912):1540-1. doi: 10.1126/science.166.3912.1540.

Ecdysone analog: conversion to alpha ecdysone and 20-hydroxyecdysone by an insect.

Science (New York, N.Y.)

J N Kaplanis, W E Robbins, M J Thompson, A H Baumhover

PMID: 17742855 DOI: 10.1126/science.166.3912.1540

Abstract

The tritium-labeled synthetic ecdysone analog Delta(7)-5beta-cholestene-2beta,-3beta,14alpha-triol-6-one terminated diapause when injected into diapausing tobacco hornworm pupae and was converted into tritium-labeled alpha-ecdysone and tritium-labeled 20-hydroxyecdysone. About half of the crystalline alpha-ecdysone and 20-hydroxyecdysone isolated from the tobacco hornworms 7(1/2) to 8(1/2) days after injection was derived from endogenous steroid precursors and half from the transformation of the synthetic ecdysone analog.

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