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Polidora VJ, Cunningham RF, Waisman HA. Phenylketonuria in rats: reversibility of behavorial deficit. Science. 1966;151(3707):219-21doi: 10.1126/science.151.3707.219.
Polidora, V. J., Cunningham, R. F., & Waisman, H. A. (1966). Phenylketonuria in rats: reversibility of behavorial deficit. Science (New York, N.Y.), 151(3707), 219-21. https://doi.org/10.1126/science.151.3707.219
Polidora, V J, et al. "Phenylketonuria in rats: reversibility of behavorial deficit." Science (New York, N.Y.) vol. 151,3707 (1966): 219-21. doi: https://doi.org/10.1126/science.151.3707.219
Polidora VJ, Cunningham RF, Waisman HA. Phenylketonuria in rats: reversibility of behavorial deficit. Science. 1966 Jan 14;151(3707):219-21. doi: 10.1126/science.151.3707.219. PMID: 17746340.
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Science. 1966 Jan 14;151(3707):219-21. doi: 10.1126/science.151.3707.219.

Phenylketonuria in rats: reversibility of behavorial deficit.

Science (New York, N.Y.)

V J Polidora, R F Cunningham, H A Waisman

PMID: 17746340 DOI: 10.1126/science.151.3707.219

Abstract

Phenylketonuria was induced in hooded rats by the conventional procedure of feeding excessive quantities of L-phenylalanine after weaning. Although this procedure reliably induced large, dose-dependent deficits in performance on a water maze, the behavioral deficits were completely eliminated after cessation of phenylalanine loading. These results cast doubt on the assumption that this animal preparation adequately simulates the irreversible intellectual impairments found in the child with late-detected phenylketonuria.

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