Display options
Cite
Ikegami T, Matsuzaki Y. Ursodeoxycholic acid: Mechanism of action and novel clinical applications. Hepatol Res. 2007;38(2):123-31doi: 10.1111/j.1872-034X.2007.00297.x.
Ikegami, T., & Matsuzaki, Y. (2008). Ursodeoxycholic acid: Mechanism of action and novel clinical applications. Hepatology research : the official journal of the Japan Society of Hepatology, 38(2), 123-31. https://doi.org/10.1111/j.1872-034X.2007.00297.x
Ikegami, Tadashi, and Matsuzaki, Yasushi. "Ursodeoxycholic acid: Mechanism of action and novel clinical applications." Hepatology research : the official journal of the Japan Society of Hepatology vol. 38,2 (2008): 123-31. doi: https://doi.org/10.1111/j.1872-034X.2007.00297.x
Ikegami T, Matsuzaki Y. Ursodeoxycholic acid: Mechanism of action and novel clinical applications. Hepatol Res. 2008;38(2):123-31. doi: 10.1111/j.1872-034X.2007.00297.x. Epub 2007 Nov 23. PMID: 18034825.
Copy Download .nbib Format: NLM
Share it on

Hepatol Res. 2008;38(2):123-31. doi: 10.1111/j.1872-034X.2007.00297.x. Epub 2007 Nov 23.

Ursodeoxycholic acid: Mechanism of action and novel clinical applications.

Hepatology research : the official journal of the Japan Society of Hepatology

Tadashi Ikegami, Yasushi Matsuzaki

Affiliations

  1. Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan.

PMID: 18034825 DOI: 10.1111/j.1872-034X.2007.00297.x

Abstract

Ursodeoxycholic acid (UDCA) is used in the treatment of cholestatic liver diseases, gallstone dissolution, and for patients with hepatitis C virus infection to ameliorate elevated alanine aminotransferase levels. The efficacy of UDCA treatment has been debated and the mechanisms of action in humans have still not defined. Suggested mechanisms include the improvement of bile acid transport and/or detoxification, cytoprotection, and anti-apoptotic effects. In this review, we summarize the proposed molecular mechanisms for the action of UDCA, especially in hepatocytes, and also discuss the putative future clinical usage of this unique drug.

Publication Types