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Vesell ES. Induction of drug-metabolizing enzymes in liver microsomes of mice and rats by softwood bedding. Science. 1967;157(3792):1057-8doi: 10.1126/science.157.3792.1057.
Vesell, E. S. (1967). Induction of drug-metabolizing enzymes in liver microsomes of mice and rats by softwood bedding. Science (New York, N.Y.), 157(3792), 1057-8. https://doi.org/10.1126/science.157.3792.1057
Vesell, E S. "Induction of drug-metabolizing enzymes in liver microsomes of mice and rats by softwood bedding." Science (New York, N.Y.) vol. 157,3792 (1967): 1057-8. doi: https://doi.org/10.1126/science.157.3792.1057
Vesell ES. Induction of drug-metabolizing enzymes in liver microsomes of mice and rats by softwood bedding. Science. 1967 Sep 01;157(3792):1057-8. doi: 10.1126/science.157.3792.1057. PMID: 17770428.
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Science. 1967 Sep 01;157(3792):1057-8. doi: 10.1126/science.157.3792.1057.

Induction of drug-metabolizing enzymes in liver microsomes of mice and rats by softwood bedding.

Science (New York, N.Y.)

E S Vesell

PMID: 17770428 DOI: 10.1126/science.157.3792.1057

Abstract

Induction of three drug-metabolizing enzymes occurred in liver microsomes of mice and rats kept on softwood bedding of either red cedar, white pine, or ponderosa pine. This induction was reversed when animals were placed on hardwood bedding composed of a mixture of beech, birch, and maple. Differences in the capacity of various beddings to induce may partially explain divergent results of studies on drug-metabolizing enzymes. The presence of such inducing substances in the environment may influence the pharmacologic responsiveness of animals to a wide variety of drugs.

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