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Shetty S, Udupa S, Udupa L. Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats. Evid Based Complement Alternat Med. 2008;5(1):95-101doi: 10.1093/ecam/nem004.
Shetty, S., Udupa, S., & Udupa, L. (2008). Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats. Evidence-based complementary and alternative medicine : eCAM, 5(1), 95-101. https://doi.org/10.1093/ecam/nem004
Shetty, Somashekar, et al. "Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats." Evidence-based complementary and alternative medicine : eCAM vol. 5,1 (2008): 95-101. doi: https://doi.org/10.1093/ecam/nem004
Shetty S, Udupa S, Udupa L. Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats. Evid Based Complement Alternat Med. 2008 Mar;5(1):95-101. doi: 10.1093/ecam/nem004. PMID: 18317555; PMCID: PMC2249741.
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Evid Based Complement Alternat Med. 2008 Mar;5(1):95-101. doi: 10.1093/ecam/nem004.

Evaluation of Antioxidant and Wound Healing Effects of Alcoholic and Aqueous Extract of Ocimum sanctum Linn in Rats.

Evidence-based complementary and alternative medicine : eCAM

Somashekar Shetty, Saraswati Udupa, Laxminarayana Udupa

Affiliations

  1. Department of Biochemistry, Melaka Manipal Medical College, Department of Biochemistry, KMC International Centre and Department of Pharmacology, Kasturba Medical College, Manipal 576104, India.

PMID: 18317555 PMCID: PMC2249741 DOI: 10.1093/ecam/nem004

Abstract

In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Ocimum sanctum (O. sanctum), a plant widely used in Ayurveda, possesses anti-inflammatory and antioxidant properties. The present study was undertaken to assess the potential of alcoholic and aqueous extracts in wound healing in Wistar albino rats. The rats were divided into five groups of six animals each. Group 1 is normal wounded control and the other four groups were treated with two different doses each of alcoholic and aqueous extract of O. sanctum. The wound healing parameters were evaluated by using incision, excision and dead space wounds in extract-treated rats and controls. Both the doses of alcoholic and aqueous extract significantly increased wound breaking strength, hydroxyproline, hexuronic acid, hexosamines, superoxide dismutase, catalase, reduced glutathione and significantly decreased percentage of wound contraction and lipid peroxidation when compared with the control group. The results suggest that O. sanctum has antioxidant properties, which may be responsible and favorable for faster wound healing and this plant extract may be useful in the management of abnormal healing and hypertropic scars.

Keywords: Ocimum sanctum; antioxidant property; wound healing activity

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