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Braschler T, Theytaz J, Zvitov-Marabi R, et al. A virtual valve for smooth contamination-free flow switching. Lab Chip. 2007;7(9):1111-3doi: 10.1039/b708360b.
Braschler, T., Theytaz, J., Zvitov-Marabi, R., van Lintel, H., Loche, G., Kunze, A., Demierre, N., Tornay, R., Schlund, M., & Renaud, P. (2007). A virtual valve for smooth contamination-free flow switching. Lab on a chip, 7(9), 1111-3. https://doi.org/10.1039/b708360b
Braschler, Thomas, et al. "A virtual valve for smooth contamination-free flow switching." Lab on a chip vol. 7,9 (2007): 1111-3. doi: https://doi.org/10.1039/b708360b
Braschler T, Theytaz J, Zvitov-Marabi R, van Lintel H, Loche G, Kunze A, Demierre N, Tornay R, Schlund M, Renaud P. A virtual valve for smooth contamination-free flow switching. Lab Chip. 2007 Sep;7(9):1111-3. doi: 10.1039/b708360b. Epub 2007 Jul 20. PMID: 17713607.
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Lab Chip. 2007 Sep;7(9):1111-3. doi: 10.1039/b708360b. Epub 2007 Jul 20.

A virtual valve for smooth contamination-free flow switching.

Lab on a chip

Thomas Braschler, Joel Theytaz, Ronit Zvitov-Marabi, Harald van Lintel, Grazia Loche, Anja Kunze, Nicolas Demierre, Raphael Tornay, Mario Schlund, Philippe Renaud

Affiliations

  1. EPFL, LMIS 4, Station 17, BM3125, Lausanne, VD 1015, Switzerland. [email protected]

PMID: 17713607 DOI: 10.1039/b708360b

Abstract

We present a channel geometry that allows for clean switching between different inlets of a microchip without any contamination of the inlets or the downstream flow. We drive this virtual valve with a pneumatic pressure setup that minimizes disturbance of the downstream flow during the switching procedure by simultaneous variation of the pressures applied to the different inlets. We assess the efficiency of the setup by spectroscopic measurement of downstream dye concentrations, and demonstrate its practical utility by sequentially constructing multiple layers of alginate hydrogel. The method is potentially useful for a whole series of further applications, such as changing perfusion liquids for cell culture and cell analysis, metering, chemical-reaction initiation and multi-sample chromatography, to name a few.

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